HELP     Sign In
construct
F_DNL2^K017_KO_HM
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Ataxia1
Decreased
Description: Mutants do not separate translational and rotation activity but instead continue walking into the rotational phase whereas wild-type flies change walking direction by stopping, turning, and then continuing to walk.
Exp Paradigm: Featureless round arena with 5 males and 5 females of the same genotype

Open field test adult stage
Social behavior Aggression1
Decreased
Description: When aggressive encounters were initiated in equal genotype assays, their duration was similar in wildtype and mutant males.

Competitive courtship assay adult stage
Social behavior Social interaction1
Decreased
Description: Mutants show greater median distance of individual flies to all other flies in a featureless round arena compared to controls.
Exp Paradigm: Featureless round arena with 5 males and 5 females of the same genotype

Open field test adult stage
Social behavior Aggression1
Decreased
Description: In assays with males from mixed genotypes mutant flies spent less time performing agonistic behaviours than wild type flies.

Competitive courtship assay adult stage
Social behavior Mating behavior1
Decreased
Description: Individual courtship bouts of mutant males were shorter than those of wild type males in mixed genotype assays.

Competitive courtship assay adult stage
Social behavior Social memory1
Decreased
Description: Mutants males adjusted more slowly to retracting their wing after a courted female moved away compared to controls.
Exp Paradigm: Featureless round arena with 5 males and 5 females of the same genotype

Open field test adult stage
Social behavior Aggression1
Decreased
Description: The tendency to initiate aggressive encounters of mutant males compared to wild type males was reduced in equal genotype assays.

Competitive courtship assay adult stage
Social behavior Mating behavior1
Abnormal
Description: Mutants spent much longer periods with one extended wing after a courted female moved away compared to controls.
Exp Paradigm: Featureless round arena with 5 males and 5 females of the same genotype

Open field test adult stage
Social behavior Mating behavior1
Increased
Description: Individual courtship bouts of mutant males were longer than those of wild type males in equal genotype assays.

Competitive courtship assay adult stage
Social behavior Social interaction: opposite sex1
Decreased
Description: Mutants sing with shorted inter pulse intervals compared to controls.

Spectographic analysis of vocalization recordings adult stage
Social behavior Aggression1
Decreased
Description: The tendency to initiate aggressive encounters of mutant males compared to wild type males was enhanced (due to low initiation frequency of wild types) during direct competition in mixed genotype assays.

Competitive courtship assay adult stage
Social behavior Mating behavior1
Decreased
Description: Mutants show reduction in the time spent courting females when caged with males of the other genotype, compared to wildtype controls.

Competitive courtship assay adult stage
Social behavior Aggression1
Decreased
Description: When aggressive encounters were initiated in mixed genotype assays, their duration was significantly prolonged in wild type males and reduced in mutant males.

Competitive courtship assay adult stage
Social behavior Social interaction: opposite sex1
Decreased
Description: Mutants sinf sine songs at normal frequency but reduced volume compared to controls.

Spectographic analysis of vocalization recordings adult stage
Social behavior Aggression1
Decreased
Description: In assays with males of equal genotype mutant flies spent less time performing agonistic behaviours than wild type flies.

Competitive courtship assay adult stage
Social behavior Mating behavior1
Decreased
Description: Mutants show decrease in the frequency of initiating courting females when caged with males of the mixed genotype, compared to controls.

Competitive courtship assay adult stage
Circadian sleep/wake cycle Locomotor activity in diurnal cycle1 No change Beam crossing adult stage
Neurophysiology Local field potential1 No change Electroretinogram (erg) adult stage
Neurophysiology Local field potential1 No change Electroretinogram (erg) adult stage
Neurophysiology Local field potential1 No change Field potential recordings adult stage
Social behavior Mating behavior1 No change Competitive courtship assay adult stage
Social behavior Mating behavior1 No change Competitive courtship assay adult stage
Social behavior Social interaction: opposite sex1 No change Spectographic analysis of vocalization recordings adult stage
Not Reported: Communications,  Developmental profile,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Neuroanatomy / ultrastructure / cytoarchitecture,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  
 
References: 1:  Hahn N , et al. 2013
HELP
Copyright © 2017 MindSpec, Inc.