Z_CNTNAP2A_1_DM_HM_BIOCHANIN-A/1.0UM

Z_CNTNAP2A_1_DM_HM_BIOCHANIN-A/1.0UM
Model Details

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Phenotypic Profile

Category

Entity

Quantity

Experimental Paradigm

Age at Testing

Motor phenotype

Hyperactivity¹

Refractory

Description: Treatment with 1.0 uM biochanin A had no effect on nighttime hyperactivity in cntnap2ab mutants, who were indistinguishable from controls.

General observations

5 dpf

Molecular profile

Gene expression¹

Refractory

Description: Treatment with 1.0 uM biochanin A had no effect on expression of cyp19a1b, vtg1, or esr1 estrogen response genes in cntnap2ab mutants.

Quantitative pcr (qrt-pcr)

4-5 dpf

Not Reported:

Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior,

References:

1: Hoffman EJ , et al. 2016

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