| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Hyperactivity1 |
Ameliorated
Description: Treatment with 0.1 uM biochanin A ameliorated nighttime hyperactivity in cntnap2ab mutants with little effect on other measures of rest and activity.
|
General observations |
5 dpf |
| |
|
Description: Treatment with 0.1 uM biochanin A ameliorated nighttime hyperactivity in cntnap2ab mutants with little effect on other measures of rest and activity.
|
|
|
| Motor phenotype |
Hyperactivity1 |
No sustained effect
Description: Chronic exposure to 0.1 uM biochanin A followed by washout did not have an effect on nighttime hyperactivity in cntnap2ab mutants.
|
General observations |
5 dpf |
| |
|
Description: Chronic exposure to 0.1 uM biochanin A followed by washout did not have an effect on nighttime hyperactivity in cntnap2ab mutants.
|
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: interneurons1 |
Refractory
Description: Early (30 hpf) exposure to 0.1 uM biochanin A had no effect on the number of GABAergic neurons in cntnap2ab mutants.
|
Immunohistochemistry |
4 dpf |
| |
|
Description: Early (30 hpf) exposure to 0.1 uM biochanin A had no effect on the number of GABAergic neurons in cntnap2ab mutants.
|
|
|
| Seizure |
Seizures1 |
Refractory
Description: Early (24 hpf to 4 dpf) exposure to 0.1 uM biochanin A had no effect on pentylenetetrazol-induced seizures in cntnap2ab mutants.
Exp Paradigm: Pentylenetetrazol
|
Observation of chemically induced seizures |
4 dpf |
| |
|
Description: Early (24 hpf to 4 dpf) exposure to 0.1 uM biochanin A had no effect on pentylenetetrazol-induced seizures in cntnap2ab mutants.
Exp Paradigm: Pentylenetetrazol |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neurophysiology, Physiological parameters, Repetitive behavior, Sensory, Social behavior, |
