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construct
M_NF1_6_KO_HM
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Learning & memory Spatial learning1
Abnormal
Description: Abnormal spatial learning
Exp Paradigm: Hidden platform test for spatial memory and navigation.

Morris water maze test Unreported
Learning & memory Cued or contextual fear conditioning: context discrimination1
Abnormal
Description: Abnormal contextual discrimination
Exp Paradigm: Discrimination between two similar chambers with the mice receiving a foot shock in one chamber

NA Unreported
Developmental profile Developmental trajectory1 No change General observations Unreported
Molecular profile Protein expression level evidence1 No change Western blot Unreported
Molecular profile Regulation of gene expression1 No change Quantitative pcr (qrt-pcr) Unreported
Motor phenotype Motor coordination and balance1 No change Accelerating rotarod test Unreported
Motor phenotype Motor coordination and balance1 No change Accelerating rotarod test Unreported
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology1 No change Histology Unreported
Sensory Vision1 No change Morris water maze test Unreported
Sensory Vision1 No change Morris water maze test Unreported
Social behavior Social transmission of food preference1 No change NA Unreported
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Maternal behavior,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  
 
References: 1:  Costa RM , et al. 2001
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