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M_NF1_4_KO_HT_IPA3
Model Details
Change
No Change
Phenotypic Profile
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Social behavior
Social memory
1
Restored
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Description:
Restored preference for novel mouse at 24-hour test, compared to parent model with control drug pir3.5, and increased preference compared to wild type with control drug pir3.5
Exp Paradigm:
Reciprocal social interaction test: confined stimulus mouse - 24-hour test
Reciprocal social interaction test
Adult
Description:
Restored preference for novel mouse at 24-hour test, compared to parent model with control drug pir3.5, and increased preference compared to wild type with control drug pir3.5
Exp Paradigm:
Reciprocal social interaction test: confined stimulus mouse - 24-hour test
Molecular profile
Protein expression level evidence
1
Restored
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Description:
Restored number of adam22 immunoreactive cells in the bla
Exp Paradigm:
Immunohistochemistry: adam22 antibody
Immunohistochemistry
Adult
Description:
Restored number of adam22 immunoreactive cells in the bla
Exp Paradigm:
Immunohistochemistry: adam22 antibody
Not Reported:
Circadian sleep/wake cycle
,
Communications
,
Developmental profile
,
Emotion
,
Immune response
,
Learning & memory
,
Maternal behavior
,
Motor phenotype
,
Neuroanatomy / ultrastructure / cytoarchitecture
,
Neurophysiology
,
Physiological parameters
,
Repetitive behavior
,
Seizure
,
Sensory
,
References:
1:
Molosh AI , et al. 2014
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