| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Circadian sleep/wake cycle |
Rapid eye movement sleep (rems)3 |
Abnormal
Description: Abnormal REM sleep
|
Electroencephalogram (eeg) |
|
| |
|
Description: Abnormal REM sleep
|
|
|
| Circadian sleep/wake cycle |
Non rapid eye movement sleep (nrems)3 |
Abnormal
Description: Abnormal NREM sleep
|
Electroencephalogram (eeg) |
|
| |
|
Description: Abnormal NREM sleep
|
|
|
| Motor phenotype |
General locomotor activity: ambulatory activity3 |
Increased
Description: Increased distance traveled
|
Open field test |
|
| |
|
Description: Increased distance traveled
|
|
|
| Motor phenotype |
General locomotor activity3 |
Increased
Description: Increased locomotor activity
|
Home cage behavior |
|
| |
|
Description: Increased locomotor activity
|
|
|
| Neurophysiology |
Neurotransmitter release: glutamate2 |
Decreased
Description: Nlgn3 knockout rats have reduced levels of glutamate in the medial prefrontal cortex and striatum compared to wild type controls.
Exp Paradigm: Measurement of glutamate concentration in the brain
|
Magnetic resonance spectroscopy (mrs) |
3-4 months |
| |
|
Description: Nlgn3 knockout rats have reduced levels of glutamate in the medial prefrontal cortex and striatum compared to wild type controls.
Exp Paradigm: Measurement of glutamate concentration in the brain |
|
|
| Neurophysiology |
Event related oscillations (eros) in electroencephalography (eeg)3 |
Abnormal
Description: Abnormal sleep patterns
|
Electroencephalogram (eeg) |
|
| |
|
Description: Abnormal sleep patterns
|
|
|
| Repetitive behavior |
Stereotypy: chewing behavior3 |
Increased
Description: Increased chewing behavior
|
General observations |
|
| |
|
Description: Increased chewing behavior
|
|
|
| Sensory |
Sensorimotor gating3 |
Decreased
Description: Decreased prepulse inhibition
|
Prepulse inhibition |
|
| |
|
Description: Decreased prepulse inhibition
|
|
|
| Social behavior |
Juvenile play1 |
Decreased
Description: Decreased play behaviors
Exp Paradigm: Reciprocal social interaction test
|
Reciprocal social interaction test |
Unreported |
| |
|
Description: Decreased play behaviors
Exp Paradigm: Reciprocal social interaction test |
|
|
| Molecular profile |
Targeted expression1 |
Decreased
Description: Decreased expression of Nlgn3
Exp Paradigm: Western blot
|
Western blot |
Unreported |
| |
|
Description: Decreased expression of Nlgn3
Exp Paradigm: Western blot |
|
|
| Molecular profile |
Metabolite levels: neurometabolites2 |
No change |
Magnetic resonance spectroscopy (mrs) |
3-4 months |
| Neurophysiology |
Neurotransmitter release: gaba2 |
No change |
Magnetic resonance spectroscopy (mrs) |
3-4 months |
| Sensory |
Startle response: acoustic stimulus3 |
No change |
Startle response test |
|
| Social behavior |
Juvenile play3 |
No change |
Reciprocal social interaction test |
|
| Social behavior |
Social approach1 |
No change |
Three-chamber social approach test |
Unreported |
| Social behavior |
Social approach3 |
No change |
Three-chamber social approach test |
|
| Social behavior |
Social interaction3 |
No change |
Reciprocal social interaction test |
|
| Social behavior |
Social memory1 |
No change |
Three-chamber social approach test |
Unreported |
| Social behavior |
Social scent marking or recognition3 |
No change |
Three-chamber social approach test |
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
