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M_NLGN3_7_CKO_NESTIN-CRE
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Hyperactivity1
Increased
Description: Increased total distance traveled and increased number of ambulatory episodes, compared to nl3-cko littermate controls
Exp Paradigm: Open field test, illuminated 60-minute session

Open field test 6 weeks
Molecular profile Targeted expression1
Decreased
Description: Complete loss of nl3 protein in whole brain, compared to nl3-cko littermate controls
Exp Paradigm: Western blot

Western blot 4 weeks
Molecular profile Gene expression1
Decreased
Description: Complete loss of nlgn3 mrna in whole brain, compared to nl3-cko littermate controls
Exp Paradigm: Quantitative pcr (qrt-pcr)

Quantitative pcr (qrt-pcr) 4 weeks
Molecular profile Gene expression1 No change Quantitative pcr (qrt-pcr) 4 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Developmental profile,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Rothwell PE , et al. 2014
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