| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance1 |
Increased
Description: Normal initial coordination with increased learning rate, compared to male littermate controls
Exp Paradigm: Accelerating rotarod, six trials 4 to 40 rpm in 300 s, six more trials 8 to 80 rpm in 300 s
|
Accelerating rotarod test |
6 weeks |
| |
|
Description: Normal initial coordination with increased learning rate, compared to male littermate controls
Exp Paradigm: Accelerating rotarod, six trials 4 to 40 rpm in 300 s, six more trials 8 to 80 rpm in 300 s |
|
|
| Motor phenotype |
Hyperactivity1 |
Increased
Description: Increased total distance traveled and increased number of ambulatory episodes, compared to male littermate controls, no change in speed
Exp Paradigm: Open field test, illuminated 60-minute session
|
Open field test |
6 weeks |
| |
|
Description: Increased total distance traveled and increased number of ambulatory episodes, compared to male littermate controls, no change in speed
Exp Paradigm: Open field test, illuminated 60-minute session |
|
|
| Repetitive behavior |
Stereotypy1 |
Increased
Description: Increased time spent ambulatory and performing stereotypic movements, increased number of wall jumps and abnormal bias in the direction of rotation during locomotion
Exp Paradigm: Open field test, illuminated 60-minute session
|
Open field test |
6 weeks |
| |
|
Description: Increased time spent ambulatory and performing stereotypic movements, increased number of wall jumps and abnormal bias in the direction of rotation during locomotion
Exp Paradigm: Open field test, illuminated 60-minute session |
|
|
| Repetitive behavior |
Stereotypy1 |
Increased
Description: Increased force variance during periods of low mobility
Exp Paradigm: Force plate actometer assay, 25-minute sessions at similar time of day
|
Force plate actometer test |
6 weeks |
| |
|
Description: Increased force variance during periods of low mobility
Exp Paradigm: Force plate actometer assay, 25-minute sessions at similar time of day |
|
|
| Repetitive behavior |
Perseveration1 |
Increased
Description: Increased repetitive behavior with training by observed reduction of variability of vertical location of each step, step length and time between steps, compared to male littermate controls
Exp Paradigm: Accelerating rotarod, first 30 s of trial 7 and trial 12 (8 to 80 rpm)
|
Accelerating rotarod test |
6 weeks |
| |
|
Description: Increased repetitive behavior with training by observed reduction of variability of vertical location of each step, step length and time between steps, compared to male littermate controls
Exp Paradigm: Accelerating rotarod, first 30 s of trial 7 and trial 12 (8 to 80 rpm) |
|
|
| Emotion |
Anxiety1 |
No change |
Open field test |
6 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Seizure, Sensory, Social behavior, |
