| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Hyperactivity1 |
Increased
Description: Increased total distance traveled, mean velocity, compared to wild type
Exp Paradigm: Open field test, mice were not nave
|
Open field test |
12-15 weeks |
| |
|
Description: Increased total distance traveled, mean velocity, compared to wild type
Exp Paradigm: Open field test, mice were not nave |
|
|
| Motor phenotype |
Hyperactivity1 |
Increased
Description: Increased total distance traveled, mean velocity, compared to wild type
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
12-15 weeks |
| |
|
Description: Increased total distance traveled, mean velocity, compared to wild type
Exp Paradigm: Elevated plus maze test |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
Decreased
Description: Decreased volume of brain, excluding olfactory bulb, cerebellum and brainstem
Exp Paradigm: Magnetic resonance imaging
|
Magnetic resonance imaging (mri) |
12-15 weeks |
| |
|
Description: Decreased volume of brain, excluding olfactory bulb, cerebellum and brainstem
Exp Paradigm: Magnetic resonance imaging |
|
|
| Sensory |
Olfaction1 |
Decreased
Description: Decreased response, measured by increased latency in food finding, compared to wild type
Exp Paradigm: Buried food test with no cues, mice were not nave
|
Buried food test |
12-15 weeks |
| |
|
Description: Decreased response, measured by increased latency in food finding, compared to wild type
Exp Paradigm: Buried food test with no cues, mice were not nave |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Decreased preference for novel social target, compared to wild type
Exp Paradigm: Three-chamber social approach test: social novelty, mice were not nave
|
Three-chamber social approach test |
12-15 weeks |
| |
|
Description: Decreased preference for novel social target, compared to wild type
Exp Paradigm: Three-chamber social approach test: social novelty, mice were not nave |
|
|
| Communications |
Ultrasonic vocalization1 |
Decreased
Description: Decreased response, measured by increased latency to initiate ultrasonic vocalizations in respose to female in estrous and decreased number of calls
Exp Paradigm: Call latency towards an unfamiliar female mouse in estrous, mice were not nave
|
Monitoring ultrasonic vocalizations |
12-15 weeks |
| |
|
Description: Decreased response, measured by increased latency to initiate ultrasonic vocalizations in respose to female in estrous and decreased number of calls
Exp Paradigm: Call latency towards an unfamiliar female mouse in estrous, mice were not nave |
|
|
| Emotion |
Exploratory activity1 |
Increased
Description: Increased number of holes explored in hole-board test
Exp Paradigm: Hole-board test, mice were not nave
|
Hole-board test |
12-15 weeks |
| |
|
Description: Increased number of holes explored in hole-board test
Exp Paradigm: Hole-board test, mice were not nave |
|
|
| Learning & memory |
Cued or contextual fear conditioning: memory of cue1 |
Decreased
Description: Decreased memory, measured by decreased freezing time in response to acoustic cue, compared to wild type
Exp Paradigm: Fear conditioning test: acoustic cue-dependent
|
Fear conditioning test |
12-15 weeks |
| |
|
Description: Decreased memory, measured by decreased freezing time in response to acoustic cue, compared to wild type
Exp Paradigm: Fear conditioning test: acoustic cue-dependent |
|
|
| Learning & memory |
Cued or contextual fear conditioning: memory of context1 |
Decreased
Description: Decreased memory, measured by decreased freezing time in response to context, compared to wild type
Exp Paradigm: Fear conditioning test: contextual
|
Fear conditioning test |
12-15 weeks |
| |
|
Description: Decreased memory, measured by decreased freezing time in response to context, compared to wild type
Exp Paradigm: Fear conditioning test: contextual |
|
|
| Learning & memory |
Cognitive flexibility1 |
Increased
Description: Increased cognitive flexibility measured by decreased latency to reach hidden platform in new location on first trial, but no change in learning rate of new location, and no change in time spent in new target quadrant in probe trial after learning, compared to wild type
Exp Paradigm: Morris water maze test: reversal learning, 8 trials, mice were not nave
|
Morris water maze test |
12-15 weeks |
| |
|
Description: Increased cognitive flexibility measured by decreased latency to reach hidden platform in new location on first trial, but no change in learning rate of new location, and no change in time spent in new target quadrant in probe trial after learning, compared to wild type
Exp Paradigm: Morris water maze test: reversal learning, 8 trials, mice were not nave |
|
|
| Developmental profile |
Size/growth1 |
No change |
General observations |
12-15 weeks |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
12-15 weeks |
| Emotion |
Anxiety1 |
No change |
Open field test |
12-15 weeks |
| Learning & memory |
Spatial learning1 |
No change |
Morris water maze test |
12-15 weeks |
| Learning & memory |
Spatial learning1 |
No change |
Morris water maze test |
12-15 weeks |
| Learning & memory |
Spatial reference memory1 |
No change |
Morris water maze test |
12-15 weeks |
| Motor phenotype |
Motor coordination and balance1 |
No change |
Accelerating rotarod test |
12-15 weeks |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
12-15 weeks |
| Sensory |
Taste1 |
No change |
Sucrose preference test |
12-15 weeks |
| Social behavior |
Social approach1 |
No change |
Three-chamber social approach test |
12-15 weeks |
| Social behavior |
Social interaction1 |
No change |
Reciprocal social interaction test |
12-15 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Immune response, Maternal behavior, Molecular profile, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, |
