| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Decreased
Description: Decrease in line crossings
|
Open field test |
5 months |
| |
|
Description: Decrease in line crossings
|
|
|
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Decreased
Description: Decreased number of chamber crossings
|
Three-chamber social approach test |
5 months |
| |
|
Description: Decreased number of chamber crossings
|
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Synapse density1 |
Decreased
Description: decrease in PSD-95 and Shank3 expression
Exp Paradigm: whole brain lysate
|
Western blot |
5 months |
| |
|
Description: decrease in PSD-95 and Shank3 expression
Exp Paradigm: whole brain lysate |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: excitatory neurons1 |
Decreased
Description: VGluT puncta
Exp Paradigm: CA1, CA3 and sensory cortex
|
Immunohistochemistry |
5 months |
| |
|
Description: VGluT puncta
Exp Paradigm: CA1, CA3 and sensory cortex |
|
|
| Social behavior |
Social approach1 |
Decreased
Description: preference for empty chamber and no preference in sniffing time between empty target or stranger
|
Three-chamber social approach test |
5 months |
| |
|
Description: preference for empty chamber and no preference in sniffing time between empty target or stranger
|
|
|
| Social behavior |
Social memory1 |
Decreased
Description: preference in sniffing time for familiar target and no preference in chamber time between familiar and stranger targets
|
Three-chamber social approach test |
5 months |
| |
|
Description: preference in sniffing time for familiar target and no preference in chamber time between familiar and stranger targets
|
|
|
| Emotion |
Exploratory activity1 |
Decreased
Description: decreased sniffing time and chamber time in all chambers
|
Three-chamber social approach test |
5 months |
| |
|
Description: decreased sniffing time and chamber time in all chambers
|
|
|
| Emotion |
Exploratory activity1 |
Decreased
Description: Decreased exploration of novel arms
|
Y-maze test |
5 months |
| |
|
Description: Decreased exploration of novel arms
|
|
|
| Learning & memory |
Spatial reference memory1 |
Decreased
Description: Time in target quadrant and number of entries into target quadrant decreased
|
Morris water maze test |
5 months |
| |
|
Description: Time in target quadrant and number of entries into target quadrant decreased
|
|
|
| Learning & memory |
Spatial learning1 |
Decreased
Description: Latency to target increased in days 1 and 5, distance to target increased in days 1, 2 and 5
|
Morris water maze test |
5 months |
| |
|
Description: Latency to target increased in days 1 and 5, distance to target increased in days 1, 2 and 5
|
|
|
| Motor phenotype |
Swimming ability1 |
No change |
Morris water maze test |
5 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: inhibitory neurons1 |
No change |
Immunohistochemistry |
5 months |
|
| Not Reported: |
|
