| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Hyperactivity1 |
Increased
Description: Increase in the number of beam breaks, but not screen touches and tray entries
|
Home cage behavior |
12 weeks |
| |
|
Description: Increase in the number of beam breaks, but not screen touches and tray entries
|
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Reaction time: cognitive flexibility1 |
Decreased
Description: Decrease in response latency for correct response but not for incorrect response or reward collection
|
Pairwise visual discrimination task |
12 weeks |
| |
|
Description: Decrease in response latency for correct response but not for incorrect response or reward collection
|
|
|
| Learning & memory |
Visual discrimination learning1 |
Increased
Description: No change in the number of trials from first presentation to 80% correct criterion; decrease in the number of correction trials to reach criterion
|
Pairwise visual discrimination task |
12 weeks |
| |
|
Description: No change in the number of trials from first presentation to 80% correct criterion; decrease in the number of correction trials to reach criterion
|
|
|
| Learning & memory |
Cognitive flexibility1 |
Increased
Description: Increase in percent of correct trials; decrease in perseveration index
|
Pairwise visual discrimination task |
12 weeks |
| |
|
Description: Increase in percent of correct trials; decrease in perseveration index
|
|
|
| Learning & memory |
Reaction time: visual discrimination1 |
No change |
Pairwise visual discrimination task |
12 weeks |
| Learning & memory |
Reward reinforced choice behavior1 |
No change |
Operant conditioning paradigm |
12 weeks |
|
| Not Reported: |
|
