| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Social behavior |
Social habituation1 |
Decreased
Description: Mutants show overall lower interaction times, no significant habituation and showed no increase in interaction in response to the nonfamiliar conspecific mice as seen in controls.
Exp Paradigm: NA
|
Habituation-dishabituation test |
Adult |
| |
|
Description: Mutants show overall lower interaction times, no significant habituation and showed no increase in interaction in response to the nonfamiliar conspecific mice as seen in controls.
Exp Paradigm: NA |
|
|
| Learning & memory |
Reward reinforced choice behavior1 |
Decreased
Description: Mutants did not develop a preference for the social compartments when conditioned in a conditioned place preference paradigm with a familiar mouse, compared with controls.
Exp Paradigm: NA
|
Conditioned place preference test |
Adult |
| |
|
Description: Mutants did not develop a preference for the social compartments when conditioned in a conditioned place preference paradigm with a familiar mouse, compared with controls.
Exp Paradigm: NA |
|
|
| Molecular profile |
Targeted expression1 |
Decreased
Description: Mutants show gfp immunofluorescence in infected neurons in the vta compared with controls. tyrosine hydroxylase positive da neurons infected with aav2-dio-mirnlgn3 are detected in the vta and substantia nigra pars compacta (snc).
Exp Paradigm: NA
|
Immunohistochemistry |
Adult |
| |
|
Description: Mutants show gfp immunofluorescence in infected neurons in the vta compared with controls. tyrosine hydroxylase positive da neurons infected with aav2-dio-mirnlgn3 are detected in the vta and substantia nigra pars compacta (snc).
Exp Paradigm: NA |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, |
