| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance3 |
Increased
Description: Normal initial coordination with increased learning rate, compared to male littermate controls
Exp Paradigm: Accelerating rotarod, nine trials 4 to 40 rpm in 300 s
|
Accelerating rotarod test |
6 weeks |
| |
|
Description: Normal initial coordination with increased learning rate, compared to male littermate controls
Exp Paradigm: Accelerating rotarod, nine trials 4 to 40 rpm in 300 s |
|
|
| Neurophysiology |
Spontaneous post synaptic events: inhibitory currents2 |
Increased
Description: Increased frequency of spontaneous mipscs in hippocampus, compared to wild type
Exp Paradigm: Whole cell patch-clamp recordings
|
Whole-cell patch clamp |
Unreported |
| |
|
Description: Increased frequency of spontaneous mipscs in hippocampus, compared to wild type
Exp Paradigm: Whole cell patch-clamp recordings |
|
|
| Neurophysiology |
Spontaneous post synaptic events: excitatory currents2 |
Decreased
Description: Decreased frequency of spontaneous mepscs in hippocampus, compared to wild type
Exp Paradigm: Whole cell patch-clamp recordings
|
Whole-cell patch clamp |
Unreported |
| |
|
Description: Decreased frequency of spontaneous mepscs in hippocampus, compared to wild type
Exp Paradigm: Whole cell patch-clamp recordings |
|
|
| Molecular profile |
Targeted expression1 |
Decreased
Description: Loss of expression of nl3 protein
Exp Paradigm: Western blot
|
Western blot |
3 months |
| |
|
Description: Loss of expression of nl3 protein
Exp Paradigm: Western blot |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: Decreased expression of nl1 protein
Exp Paradigm: Western blot
|
Western blot |
3 months |
| |
|
Description: Decreased expression of nl1 protein
Exp Paradigm: Western blot |
|
|
| Developmental profile |
General characteristics1 |
No change |
General observations |
Unreported |
| Molecular profile |
Protein expression level evidence1 |
No change |
Western blot |
3 months |
| Molecular profile |
Protein expression level evidence1 |
No change |
Western blot |
3 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Synapse density: excitatory1 |
No change |
Immunohistochemistry |
3 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Synapse density: inhibitory1 |
No change |
Immunohistochemistry |
3 months |
| Neurophysiology |
Presynaptic function: paired-pulse facilitation2 |
No change |
Field potential recordings |
Unreported |
| Neurophysiology |
Spontaneous post synaptic events: excitatory currents1 |
No change |
Whole-cell patch clamp |
Unreported |
| Neurophysiology |
Spontaneous post synaptic events: inhibitory currents1 |
No change |
Whole-cell patch clamp |
Unreported |
| Neurophysiology |
Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission2 |
No change |
Whole-cell patch clamp |
Unreported |
| Neurophysiology |
Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission2 |
No change |
Whole-cell patch clamp |
Unreported |
| Neurophysiology |
Synaptic plasticity1 |
No change |
Whole-cell patch clamp |
Unreported |
| Neurophysiology |
Synaptic plasticity: hippocampal ltp2 |
No change |
Field potential recordings |
Unreported |
| Neurophysiology |
Synaptic transmission: excitatory2 |
No change |
Field potential recordings |
Unreported |
| Neurophysiology |
Synaptic transmission: excitatory1 |
No change |
Whole-cell patch clamp |
Unreported |
| Neurophysiology |
Synaptic transmission: inhibitory1 |
No change |
Whole-cell patch clamp |
Unreported |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
