| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Increased
Description: Global nlgn3 mutants show increased velocity of locomotion in the open field compared with controls.
Exp Paradigm: NA
|
Open field test |
Adult |
| |
|
Description: Global nlgn3 mutants show increased velocity of locomotion in the open field compared with controls.
Exp Paradigm: NA |
|
|
| Neurophysiology |
Neuroreceptor activity1 |
Abnormal
Description: Global nlgn3 knockout mice show increase in rectification index of ampar mediated currents compared with controls, indicating aberrant increase of glua2-lacking ampars in nlgn3 deficient vta da neurons.
Exp Paradigm: NA
|
Whole-cell patch clamp |
4-8 weeks |
| |
|
Description: Global nlgn3 knockout mice show increase in rectification index of ampar mediated currents compared with controls, indicating aberrant increase of glua2-lacking ampars in nlgn3 deficient vta da neurons.
Exp Paradigm: NA |
|
|
| Repetitive behavior |
Repetitive digging1 |
Decreased
Description: Global nlgn3 mutants show a decrease in the total number of marbles buried compared with controls.
Exp Paradigm: NA
|
Marble-burying test |
Adult |
| |
|
Description: Global nlgn3 mutants show a decrease in the total number of marbles buried compared with controls.
Exp Paradigm: NA |
|
|
| Social behavior |
Social habituation1 |
Decreased
Description: Global nlgn3 mutants show overall lower interaction times and no significant habituation compared with controls.
Exp Paradigm: NA
|
Habituation-dishabituation test |
Adult |
| |
|
Description: Global nlgn3 mutants show overall lower interaction times and no significant habituation compared with controls.
Exp Paradigm: NA |
|
|
| Social behavior |
Social dishabituation1 |
Decreased
Description: Global nlgn3 mutants show no increase in interaction in response to the nonfamiliar conspecific mice as seen in controls.
Exp Paradigm: NA
|
Habituation-dishabituation test |
Adult |
| |
|
Description: Global nlgn3 mutants show no increase in interaction in response to the nonfamiliar conspecific mice as seen in controls.
Exp Paradigm: NA |
|
|
| Learning & memory |
Reward reinforced choice behavior1 |
Decreased
Description: Global nlgn3 mutants did not develop a preference for the social compartments when conditioned in a conditioned place preference paradigm with a familiar mouse, compared with wildtype controls.
Exp Paradigm: NA
|
Conditioned place preference test |
Adult |
| |
|
Description: Global nlgn3 mutants did not develop a preference for the social compartments when conditioned in a conditioned place preference paradigm with a familiar mouse, compared with wildtype controls.
Exp Paradigm: NA |
|
|
| Learning & memory |
Olfactory learning and memory1 |
Decreased
Description: Global nlgn3 mutants show decrease in response when presented a second novel social odor compared with controls.
Exp Paradigm: NA
|
Olfactory discrimination test |
Adult |
| |
|
Description: Global nlgn3 mutants show decrease in response when presented a second novel social odor compared with controls.
Exp Paradigm: NA |
|
|
| Emotion |
Exploratory activity: habituation1 |
No change |
Habituation-dishabituation test |
Adult |
| Learning & memory |
Object recognition memory1 |
No change |
Novel object recognition test |
Adult |
| Sensory |
Olfaction1 |
No change |
Olfactory discrimination test |
Adult |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Seizure, |
