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M_NLGN3_27_KD
Model Details
Change
No Change
Phenotypic Profile
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Molecular profile
Targeted expression
1
Decreased
View More
Description:
Mutants show decreased nl3 protein in the medial prefrontal cortex compared to controls.
Exp Paradigm:
NA
Western blot
4.5 months
Description:
Mutants show decreased nl3 protein in the medial prefrontal cortex compared to controls.
Exp Paradigm:
NA
Molecular profile
Targeted expression
1
Decreased
View More
Description:
Mutants show decreased levels of nlgn3 mrna compared to controls.
Exp Paradigm:
NA
Quantitative pcr (qrt-pcr)
2.75 months
Description:
Mutants show decreased levels of nlgn3 mrna compared to controls.
Exp Paradigm:
NA
Social behavior
Social approach
1
No change
Three-chamber social approach test
2-3 months
Social behavior
Social memory
1
No change
Three-chamber social approach test
2-3 months
Not Reported:
Circadian sleep/wake cycle
,
Communications
,
Developmental profile
,
Emotion
,
Immune response
,
Learning & memory
,
Maternal behavior
,
Motor phenotype
,
Neuroanatomy / ultrastructure / cytoarchitecture
,
Neurophysiology
,
Physiological parameters
,
Repetitive behavior
,
Seizure
,
Sensory
,
References:
1:
Cao W , et al. 2018
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