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M_NLGN3_26_KI_R451C_QUINPIROLE
Model Details
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Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Neurophysiology Miniature post synaptic current amplitude: excitatory1
No adverse effect
Description: Mutants treated with quinparole showed no change in glutamatergic excitatory post-synaptic potential amplitudes in spns compared to untreated mutants.
Exp Paradigm: Corticostrial slices were used for recordings.

Whole-cell patch clamp 2 month
Neurophysiology Membrane potential1
No adverse effect
Description: Mutants treated with quinparole show no change in resting membrane potential compared to untreated mutants.
Exp Paradigm: Corticostrial slices were used for recordings.

Whole-cell patch clamp 2 month
Neurophysiology Synaptic plasticity: striatal ltd1
Refractory
Description: Mutants treated with quinparole showed did not show restored ltd in spns compared to untreated mutants.
Exp Paradigm: Corticostrial slices were used for recordings.

Whole-cell patch clamp 2 month
Not Reported: Circadian sleep/wake cycle,  Communications,  Developmental profile,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Motor phenotype,  Neuroanatomy / ultrastructure / cytoarchitecture,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Martella G , et al. 2017
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