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construct
M_NLGN3_26_KI_R451C
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Neurophysiology Synaptic plasticity: striatal ltd1
Decreased
Description: Mutants show no change of the amplitude of evoked epsp upon high frequency stimulation compared to controls where high frequency stimulation induces ltd of of evoked epsps.
Exp Paradigm: Corticostrial slices were used for recordings.

Whole-cell patch clamp 2 month
Neurophysiology Action potential property: amplitude1 No change Whole-cell patch clamp 2 month
Neurophysiology Action potential property: firing pattern1 No change Whole-cell patch clamp 2 month
Neurophysiology Action potential property: half-width1 No change Whole-cell patch clamp 2 month
Neurophysiology Intrinsic membrane properties1 No change Whole-cell patch clamp 2 month
Neurophysiology Membrane potential1 No change Whole-cell patch clamp 2 month
Neurophysiology Miniature post synaptic current amplitude: excitatory1 No change Whole-cell patch clamp 2 month
Neurophysiology Miniature post synaptic current frequency: excitatory1 No change Whole-cell patch clamp 2 month
Neurophysiology Presynaptic function: paired-pulse facilitation1 No change Whole-cell patch clamp 2 month
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents1 No change Whole-cell patch clamp 2 month
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents1 No change Whole-cell patch clamp 2 month
Not Reported: Circadian sleep/wake cycle,  Communications,  Developmental profile,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Motor phenotype,  Neuroanatomy / ultrastructure / cytoarchitecture,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Martella G , et al. 2017
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