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construct
M_NLGN3_23_KO_HM
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype General locomotor activity: ambulatory activity1
Increased
Description: Female mutants conventionally reared show increase in total distance travelled on the open field compared to controls.
Exp Paradigm: NA

Open field test 2-4 month
Social behavior Social interaction1
Decreased
Description: Female mutants conventionally reared show decrease in social interaction with an unfamiliar female compared to controls.
Exp Paradigm: NA

Reciprocal social interaction test 2-4 month
Emotion Thigmotaxis1
Decreased
Description: Female mutants conventionally reared show decrease in distance travelled by the wall of the open field compared to controls.
Exp Paradigm: NA

Open field test 2-4 month
Emotion Anxiety1 No change Elevated plus maze test 2-4 month
Emotion Anxiety1 No change Elevated plus maze test 3-4 weeks
Emotion Anxiety1 No change Open field test 3-4 weeks
Motor phenotype General locomotor activity: ambulatory activity1 No change Open field test 3-4 weeks
Social behavior Social interaction1 No change Open field test 3-4 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Developmental profile,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  
 
References: 1:  Kalbassi S , et al. 2017
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