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M_NLGN3_21_KI_R451C_REINSTATE-NLGN3
Model Details
Change
No Change
Phenotypic Profile
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Social behavior
Social memory
1
Restored
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Description:
Re-expression of wt nl3 in the mpfc rescued social novelty deficit in ki mice.
Exp Paradigm:
NA
Three-chamber social approach test
2-3 months
Description:
Re-expression of wt nl3 in the mpfc rescued social novelty deficit in ki mice.
Exp Paradigm:
NA
Social behavior
Social approach
1
No adverse effect
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Description:
Re-expression of wt nl3 in the mpfc did not alter sociability in mutant mice.
Exp Paradigm:
NA
Three-chamber social approach test
2-3 months
Description:
Re-expression of wt nl3 in the mpfc did not alter sociability in mutant mice.
Exp Paradigm:
NA
Not Reported:
Circadian sleep/wake cycle
,
Communications
,
Developmental profile
,
Emotion
,
Immune response
,
Learning & memory
,
Maternal behavior
,
Molecular profile
,
Motor phenotype
,
Neuroanatomy / ultrastructure / cytoarchitecture
,
Neurophysiology
,
Physiological parameters
,
Repetitive behavior
,
Seizure
,
Sensory
,
References:
1:
Cao W , et al. 2018
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