| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Refractory
Description: Patterned optogenetic activation of pvalb neurons did not reduce increased locomotion in mutant mice.
Exp Paradigm: NA
|
Open field test |
2-3 months |
| |
|
Description: Patterned optogenetic activation of pvalb neurons did not reduce increased locomotion in mutant mice.
Exp Paradigm: NA |
|
|
| Neurophysiology |
Network excitability1 |
Restored
Description: Patterned optogenetic activation of pvalb neurons enhanced the power of theta and gamma bands and their coupling strength.
Exp Paradigm: NA
|
In vivo local field potential (lfp) recordings |
2-3 months |
| |
|
Description: Patterned optogenetic activation of pvalb neurons enhanced the power of theta and gamma bands and their coupling strength.
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Restored
Description: Patterned optogenetic activation of pvalb neurons enhanced social novelty preference, but not at a constant 40 hz or 8 hz-nested 20 hz stimulation. higher- frequency stimulation (80 hz) or direct inhibition of the activity of pv neurons (using nphr) impaired social novelty discrimination in both ki and wt mice.
Exp Paradigm: NA
|
Three-chamber social approach test |
2-3 months |
| |
|
Description: Patterned optogenetic activation of pvalb neurons enhanced social novelty preference, but not at a constant 40 hz or 8 hz-nested 20 hz stimulation. higher- frequency stimulation (80 hz) or direct inhibition of the activity of pv neurons (using nphr) impaired social novelty discrimination in both ki and wt mice.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
No adverse effect
Description: Patterned optogenetic activation of pvalb neurons did not affect time spent in the center of the open field in mutant mice.
Exp Paradigm: NA
|
Open field test |
2-3 months |
| |
|
Description: Patterned optogenetic activation of pvalb neurons did not affect time spent in the center of the open field in mutant mice.
Exp Paradigm: NA |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Repetitive behavior, Seizure, Sensory, |
