| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Increased
Description: Mutants travel greater distance than controls. mutants do not show an increase in the number of beam breaks over 30 h compared to controls.
Exp Paradigm: NA
|
Open field test |
3-4 weeks, 2-4 months |
| |
|
Description: Mutants travel greater distance than controls. mutants do not show an increase in the number of beam breaks over 30 h compared to controls.
Exp Paradigm: NA |
|
|
| Repetitive behavior |
Repetitive digging1 |
Decreased
Description: Mutants from single genotype housing buried fewer marbles than wildtype in single genotype housing but buried less marbles than wildtype or controls in mixed genotype housing.
Exp Paradigm: NA
|
Marble-burying test |
2-4 month |
| |
|
Description: Mutants from single genotype housing buried fewer marbles than wildtype in single genotype housing but buried less marbles than wildtype or controls in mixed genotype housing.
Exp Paradigm: NA |
|
|
| Social behavior |
Social scent marking or recognition1 |
Increased
Description: Mutant males from sgh showed increased interest toward social odors than non-social odors compared to control male mice in sgh.
Exp Paradigm: NA
|
Olfactory discrimination test |
2-4 month |
| |
|
Description: Mutant males from sgh showed increased interest toward social odors than non-social odors compared to control male mice in sgh.
Exp Paradigm: NA |
|
|
| Physiological parameters |
Hormone levels1 |
Increased
Description: Mutant males in sgh show increased testosterone levels compared to control males in sgh.
Exp Paradigm: Testosterone levels were measured in urine.
|
Elisa |
2-4 month |
| |
|
Description: Mutant males in sgh show increased testosterone levels compared to control males in sgh.
Exp Paradigm: Testosterone levels were measured in urine. |
|
|
| Communications |
Ultrasonic vocalization: interaction induced: opposite sex stimulus1 |
Decreased
Description: Mutant males mice from single group housing (sgh) show decreased ultrasonic vocalization during courtship than wildtype males from sgh. mutant males from mgh and sgh spent similar times emitting usvs in the presence of a female in estrus.
Exp Paradigm: NA
|
Monitoring ultrasonic vocalizations |
2-4 month |
| |
|
Description: Mutant males mice from single group housing (sgh) show decreased ultrasonic vocalization during courtship than wildtype males from sgh. mutant males from mgh and sgh spent similar times emitting usvs in the presence of a female in estrus.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Decreased
Description: Mutants spent increased durations in the center of the open field compared to controls and mutants housed in mixed genotype groups.
Exp Paradigm: NA
|
Open field test |
2-4 month |
| |
|
Description: Mutants spent increased durations in the center of the open field compared to controls and mutants housed in mixed genotype groups.
Exp Paradigm: NA |
|
|
| Emotion |
Thigmotaxis1 |
Decreased
Description: Mutants spend less time along the wall of the open field compared to controls.
Exp Paradigm: NA
|
Open field test |
2-4 month |
| |
|
Description: Mutants spend less time along the wall of the open field compared to controls.
Exp Paradigm: NA |
|
|
| Molecular profile |
Targeted expression1 |
Decreased
Description: Mutants show decreased expression of nlgn3 protein in the cerebellum, cortex, striatum, hippocampus, brainstem and thalamus compared to controls.
Exp Paradigm: NA
|
Western blot |
2-4 month |
| |
|
Description: Mutants show decreased expression of nlgn3 protein in the cerebellum, cortex, striatum, hippocampus, brainstem and thalamus compared to controls.
Exp Paradigm: NA |
|
|
| Circadian sleep/wake cycle |
Adaptation to dark phase1 |
No change |
Home cage behavior |
2-4 month |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
3-4 weeks |
| Emotion |
Anxiety1 |
No change |
Open field test |
3-4 weeks |
| Molecular profile |
Gene expression1 |
No change |
Quantitative pcr (qrt-pcr) |
2-4 month |
| Motor phenotype |
Spontaneous movement1 |
No change |
Spontaneous movement analysis |
2-4 month |
| Social behavior |
Social dominance1 |
No change |
Tube test of social dominance |
2-4 month |
| Social behavior |
Social interaction: with juveniles1 |
No change |
Reciprocal social interaction test |
3-4 weeks |
|
| Not Reported: |
Developmental profile, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Seizure, Sensory, |
