HELP     Sign In
construct
M_NLGN3_1_KI_R451C_PSD95-GFP
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine turnover1
Increased
Description: Nlgn3r451c mice show increased turnover of psd95-positive puncta associated spines in the afc compared to wild type mice
Exp Paradigm: Turnover of psd-95 -gfp positive puncta of spines was measured

Two-photon microscopy 3 weeks
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density1 No change Two-photon microscopy 3 weeks
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine turnover1 No change Two-photon microscopy 3 weeks
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory1 No change Two-photon microscopy 3 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Developmental profile,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Motor phenotype,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Isshiki M , et al. 2014
HELP
Copyright © 2017 MindSpec, Inc.