| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine turnover1 |
Increased
Description: Nlgn3r451c mice show increased turnover of gephyrin-negative puncta associated spines in the ssc compared to wild type mice
Exp Paradigm: Turnover of gephyrin-gfp negative puncta-associated spines was measured
|
Two-photon microscopy |
3 weeks |
| |
|
Description: Nlgn3r451c mice show increased turnover of gephyrin-negative puncta associated spines in the ssc compared to wild type mice
Exp Paradigm: Turnover of gephyrin-gfp negative puncta-associated spines was measured |
|
|
| Neurophysiology |
Neuronal activation following behavioral stimulation: c-fos levels1 |
Decreased
Description: Nlgn3r451c mice have reduced density of c-fos positive cells in the barrel cortex region corresponding to row c of whiskers, in layers 2/3 compared to wild type mice
Exp Paradigm: All whiskers except row c were removed and mice exposed to enriched environment for 1 h before sacrifice
|
Immunohistochemistry |
3 weeks |
| |
|
Description: Nlgn3r451c mice have reduced density of c-fos positive cells in the barrel cortex region corresponding to row c of whiskers, in layers 2/3 compared to wild type mice
Exp Paradigm: All whiskers except row c were removed and mice exposed to enriched environment for 1 h before sacrifice |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine density1 |
No change |
Two-photon microscopy |
3 weeks |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine turnover1 |
No change |
Histology |
3 weeks |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Synapse density: excitatory1 |
No change |
Two-photon microscopy |
3 weeks |
| Neurophysiology |
Neuronal activation following behavioral stimulation: c-fos levels1 |
No change |
Immunohistochemistry |
3 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
