| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Refractory
Description: Reexpression of nlgn3 in parvalbumin interneurons, did not reduce the total distance travelled in mutants.
Exp Paradigm: NA
|
Open field test |
2-4 month |
| |
|
Description: Reexpression of nlgn3 in parvalbumin interneurons, did not reduce the total distance travelled in mutants.
Exp Paradigm: NA |
|
|
| Social behavior |
Social scent marking or recognition1 |
Ameliorated
Description: Reexpression of nlgn3 in parvalbumin interneurons, increased the time spent investigating social odors compared to mutants.
Exp Paradigm: NA
|
Western blot |
2-4 month |
| |
|
Description: Reexpression of nlgn3 in parvalbumin interneurons, increased the time spent investigating social odors compared to mutants.
Exp Paradigm: NA |
|
|
| Social behavior |
Social interaction: with juveniles1 |
Restored
Description: Reexpression of nlgn3 in parvalbumin interneurons increased the time spent interacting with an unfamiliar adult female in juvenile mice, compared to mutants.
Exp Paradigm: NA
|
Reciprocal social interaction test |
3-4 weeks |
| |
|
Description: Reexpression of nlgn3 in parvalbumin interneurons increased the time spent interacting with an unfamiliar adult female in juvenile mice, compared to mutants.
Exp Paradigm: NA |
|
|
| Social behavior |
Social dominance1 |
Restored
Description: Reexpression of nlgn3 in parvalbumin interneurons, increased showed increased number of wins again submissive wildtype males compared to mutants.
Exp Paradigm: NA
|
Tube test of social dominance |
2-4 month |
| |
|
Description: Reexpression of nlgn3 in parvalbumin interneurons, increased showed increased number of wins again submissive wildtype males compared to mutants.
Exp Paradigm: NA |
|
|
| Communications |
Ultrasonic vocalization: interaction induced: opposite sex stimulus1 |
Refractory
Description: Reexpression of nlgn3 in parvalbumin interneurons, did not increase the time spent calling during courtship compared to mutant house in mixed genotype groups.
Exp Paradigm: NA
|
Monitoring ultrasonic vocalizations |
2-4 month |
| |
|
Description: Reexpression of nlgn3 in parvalbumin interneurons, did not increase the time spent calling during courtship compared to mutant house in mixed genotype groups.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
No adverse effect
Description: Reexpression of nlgn3 in parvalbumin interneurons, did not alter durations spent in the center of the open field and in the open arms of the elevated plus maze compared to mutants.
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
2-4 month |
| |
|
Description: Reexpression of nlgn3 in parvalbumin interneurons, did not alter durations spent in the center of the open field and in the open arms of the elevated plus maze compared to mutants.
Exp Paradigm: Elevated plus maze test |
|
|
| Emotion |
Anxiety1 |
No adverse effect
Description: Reexpression of nlgn3 in parvalbumin interneurons, did not alter durations spent in the center of the open field and in the open arms of the elevated plus maze compared to mutants.
Exp Paradigm: Open field test
|
Open field test |
2-4 month |
| |
|
Description: Reexpression of nlgn3 in parvalbumin interneurons, did not alter durations spent in the center of the open field and in the open arms of the elevated plus maze compared to mutants.
Exp Paradigm: Open field test |
|
|
| Molecular profile |
Targeted expression1 |
Restored
Description: Reexpression of nlgn3 in parvalbumin interneurons, restored neuroligin-3 protein expression in several parts of the brain, including cerebellum brainstem (0.15), striatum, thalamus, and cortex compared to mutant males.
Exp Paradigm: NA
|
Western blot |
2-4 month |
| |
|
Description: Reexpression of nlgn3 in parvalbumin interneurons, restored neuroligin-3 protein expression in several parts of the brain, including cerebellum brainstem (0.15), striatum, thalamus, and cortex compared to mutant males.
Exp Paradigm: NA |
|
|
| Molecular profile |
Targeted expression1 |
Refractory
Description: Reexpression of nlgn3 in parvalbumin interneurons did not restore nlgn3 expression in the hippocampus compared to mutants.
Exp Paradigm: NA
|
Western blot |
2-4 month |
| |
|
Description: Reexpression of nlgn3 in parvalbumin interneurons did not restore nlgn3 expression in the hippocampus compared to mutants.
Exp Paradigm: NA |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Developmental profile, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, |
