| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Repetitive behavior |
Self grooming: perseveration1 |
Increased
Description: Nlgn3-sirna injected mice show increase in repetitive self-grooming compared with controls.
Exp Paradigm: NA
|
Grooming behavior assessments |
Adult |
| |
|
Description: Nlgn3-sirna injected mice show increase in repetitive self-grooming compared with controls.
Exp Paradigm: NA |
|
|
| Repetitive behavior |
Repetitive digging1 |
Decreased
Description: Nlgn3-sirna injected mice show decrease in repetitive digging compared with controls.
Exp Paradigm: NA
|
Home cage behavior |
Adult |
| |
|
Description: Nlgn3-sirna injected mice show decrease in repetitive digging compared with controls.
Exp Paradigm: NA |
|
|
| Learning & memory |
Object recognition memory1 |
Decreased
Description: Nlgn3-sirna injected mice show decrease in time spent with an unfamiliar object over a familiar object compared with controls.
Exp Paradigm: NA
|
Object preference test |
Adult |
| |
|
Description: Nlgn3-sirna injected mice show decrease in time spent with an unfamiliar object over a familiar object compared with controls.
Exp Paradigm: NA |
|
|
| Molecular profile |
Targeted expression1 |
Decreased
Description: Nlgn3-sirna injected mice show decrease in nlgn3 transcript in the dorsal striatum, 2 days after injection.
Exp Paradigm: Striatal tissue was used for qrt pcr.
|
Quantitative pcr (qrt-pcr) |
Adult |
| |
|
Description: Nlgn3-sirna injected mice show decrease in nlgn3 transcript in the dorsal striatum, 2 days after injection.
Exp Paradigm: Striatal tissue was used for qrt pcr. |
|
|
| Social behavior |
Social memory1 |
No change |
U-field assay |
Adult |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Seizure, Sensory, |
