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M_NLGN3_14_CKO_HM_NAC
Model Details
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Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Motor coordination and balance1
Increased
Description: Normal initial coordination with increased learning rate, compared to nl3-cko littermate controls injected with catalytically inactive cre
Exp Paradigm: Accelerating rotarod, six trials 4 to 40 rpm in 300 s, six more trials 8 to 80 rpm in 300 s

Accelerating rotarod test 6 weeks
Motor phenotype Hyperactivity1
Increased
Description: Increased total distance traveled and increased number of ambulatory episodes, compared to nl3-cko littermate controls injected with catalytically inactive cre
Exp Paradigm: Open field test, illuminated 60-minute session

Open field test 6 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Developmental profile,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Rothwell PE , et al. 2014
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