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M_NLGN3_10_CKO_HM_REINSTATE-NLGN3
Model Details
Change
No Change
Phenotypic Profile
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Motor phenotype
Motor coordination and balance
1
Restored
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Description:
No change in initial coordination or learning rate, compared to nl3-cko littermate controls injected with same dio-nl3 construct
Exp Paradigm:
Accelerating rotarod, six trials 4 to 40 rpm in 300 s, six more trials 8 to 80 rpm in 300 s
Accelerating rotarod test
6 weeks
Description:
No change in initial coordination or learning rate, compared to nl3-cko littermate controls injected with same dio-nl3 construct
Exp Paradigm:
Accelerating rotarod, six trials 4 to 40 rpm in 300 s, six more trials 8 to 80 rpm in 300 s
Motor phenotype
Hyperactivity
1
Restored
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Description:
No change in total distance traveled or number of ambulatory episodes, compared to nl3-cko littermate controls injected withsame dio-nl3 construct
Exp Paradigm:
Open field test, illuminated 60-minute session
Open field test
6 weeks
Description:
No change in total distance traveled or number of ambulatory episodes, compared to nl3-cko littermate controls injected withsame dio-nl3 construct
Exp Paradigm:
Open field test, illuminated 60-minute session
Not Reported:
Circadian sleep/wake cycle
,
Communications
,
Developmental profile
,
Emotion
,
Immune response
,
Learning & memory
,
Maternal behavior
,
Molecular profile
,
Neuroanatomy / ultrastructure / cytoarchitecture
,
Neurophysiology
,
Physiological parameters
,
Repetitive behavior
,
Seizure
,
Sensory
,
Social behavior
,
References:
1:
Rothwell PE , et al. 2014
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