Description: Decreased cortical thickness, increase in cell density of cerebral cortex, no change in total cell and neuron number in cortex; no change in hippocampus and hindbrain morphology
Exp Paradigm: Histological analysis followed by morphometric analysis of serial coronal sections of brains. h&e counts and neun staining counts

Description: Limited reduction in brain size limited to forebrain
Exp Paradigm: Weight analysis

Description: Decreased brain size limited to forebrain
Exp Paradigm: Weight analysis

Description: Reduction in cortical thickness, increase in cell density, no change in total cell and neuron number
Exp Paradigm: Histological analysis followed by morphometric analysis of serial coronal sections of brains. h&e counts and neun staining counts

Description: Growth retardation; reduction in body weight and size with appropriate reduction in organs size/weight; no evidence of tumor appearance
Exp Paradigm: General observations

Description: Growth retardation from 3 to 4 days after birth sustained into adulthood; reduction in both weight and size; no evidence of tumor appearance
Exp Paradigm: General observations

Description: Absence of nf1 protein expression
Exp Paradigm: Nf1 protein expression

Description: Increased levels of downstream signaling component p-erk in layers ii/iii and vi of cerebral cortex
Exp Paradigm: Downstream signaling activation

Description: Increased astrocyte protein, astrogliosis throughout cerebral cortex, hippocampus, and brainstem; hypertrophic astrocytes with increased processes
Exp Paradigm: Astrocyte specific protein expression

Description: Complete lack of nf1 protein expression
Exp Paradigm: Nf1 protein expression