| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
Abnormal
Description: Abnormal morphology demonstrated by decreased patterning of cortical cells into barrels
Exp Paradigm: NA
|
NA |
Unreported |
| |
|
Description: Abnormal morphology demonstrated by decreased patterning of cortical cells into barrels
Exp Paradigm: NA |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Cortical lamination1 |
Decreased
Description: Decreased patterning of cortical cells into barrels; reduced cellular aggregation throughout the entire somatosensory area
Exp Paradigm: Dapi staining of coronal or tangential sections of cortex
|
Nuclear staining |
Unreported |
| |
|
Description: Decreased patterning of cortical cells into barrels; reduced cellular aggregation throughout the entire somatosensory area
Exp Paradigm: Dapi staining of coronal or tangential sections of cortex |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
Decreased
Description: Decreased size of individual patches; decreased distribution of ring-like nuclei
Exp Paradigm: Dapi staining of tangential sections across the pmbsf area
|
Nuclear staining |
P4, p10 |
| |
|
Description: Decreased size of individual patches; decreased distribution of ring-like nuclei
Exp Paradigm: Dapi staining of tangential sections across the pmbsf area |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
Abnormal
Description: Abnormal morphology of individual patches of brain slices with reduction in size and increase in width of septa between patches
Exp Paradigm: Cytochrome oxidase staining of brain sections
|
Cytochrome oxidase staining |
5 weeks |
| |
|
Description: Abnormal morphology of individual patches of brain slices with reduction in size and increase in width of septa between patches
Exp Paradigm: Cytochrome oxidase staining of brain sections |
|
|
| Molecular profile |
Protein modification process1 |
Increased
Description: Increased levels of phospho-erk in cortex
Exp Paradigm: Phospho-erk expression levels
|
Western blot |
P0, p4 |
| |
|
Description: Increased levels of phospho-erk in cortex
Exp Paradigm: Phospho-erk expression levels |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: Decreased expression of nf1 in somatosensory cortex tissue extracts
Exp Paradigm: Nf1 protein expression
|
Western blot |
P0, p4 |
| Molecular profile |
Protein expression level evidence1 |
No change |
Western blot |
P0, p4 |
| Molecular profile |
Protein expression level evidence1 |
No change |
Western blot |
P0, p4 |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
No change |
Cytochrome oxidase staining |
5 weeks |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
No change |
NA |
Unreported |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
No change |
Nuclear staining |
P4-p35 |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Somatosensory cortical map architecture1 |
No change |
Immunohistochemistry |
P4 |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
