| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Repetitive behavior |
Self grooming: perseveration1 |
Increased
Description: Mecp2-sirna injected mice show increase in repetitive self-grooming compared with controls.
Exp Paradigm: NA
|
Grooming behavior assessments |
Adult |
| |
|
Description: Mecp2-sirna injected mice show increase in repetitive self-grooming compared with controls.
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Mecp2-sirna injected mice show decrease in preference for an unfamiliar over a familiar mouse compared with controls.
Exp Paradigm: NA
|
U-field assay |
Adult |
| |
|
Description: Mecp2-sirna injected mice show decrease in preference for an unfamiliar over a familiar mouse compared with controls.
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Decreased
Description: Mecp2-sirna injected mice show significant preference for a social stimulus over an empty cage but the time spent with a social stimulus is significantly less compared with controls.
Exp Paradigm: NA
|
Three-chamber social approach test |
Adult |
| |
|
Description: Mecp2-sirna injected mice show significant preference for a social stimulus over an empty cage but the time spent with a social stimulus is significantly less compared with controls.
Exp Paradigm: NA |
|
|
| Learning & memory |
Object recognition memory1 |
Decreased
Description: Mecp2-sirna injected mice show decrease in time spent with an unfamiliar object over a familiar object compared with controls.
Exp Paradigm: NA
|
Object preference test |
Adult |
| |
|
Description: Mecp2-sirna injected mice show decrease in time spent with an unfamiliar object over a familiar object compared with controls.
Exp Paradigm: NA |
|
|
| Molecular profile |
Targeted expression1 |
Decreased
Description: Mecp2-sirna injected mice show decrease in mecp2 transcript in the dorsal striatum, 2 days after injection.
Exp Paradigm: Striatal tissue was used for qrt pcr.
|
Quantitative pcr (qrt-pcr) |
Adult |
| |
|
Description: Mecp2-sirna injected mice show decrease in mecp2 transcript in the dorsal striatum, 2 days after injection.
Exp Paradigm: Striatal tissue was used for qrt pcr. |
|
|
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
No change |
Open field test |
Adult |
| Repetitive behavior |
Repetitive digging1 |
No change |
Marble-burying test |
Adult |
| Repetitive behavior |
Repetitive digging1 |
No change |
Home cage behavior |
Adult |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Seizure, Sensory, |
