| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance1 |
Decreased
Description: Decreased motor coordination demonstrated by less time spent on the rotarod
Exp Paradigm: Rotarod test
|
Accelerating rotarod test |
Unreported |
| |
|
Description: Decreased motor coordination demonstrated by less time spent on the rotarod
Exp Paradigm: Rotarod test |
|
|
| Neurophysiology |
Synaptic plasticity1 |
Decreased
Description: Decreased synaptic plasticity demonstrated by attenuated hfs-induced ltp in hippocampal slices
Exp Paradigm: Fepsp recordings of hippocampal slices of the schaffer-collateral pathway using hfs
|
Field potential recordings |
8-12 weeks |
| |
|
Description: Decreased synaptic plasticity demonstrated by attenuated hfs-induced ltp in hippocampal slices
Exp Paradigm: Fepsp recordings of hippocampal slices of the schaffer-collateral pathway using hfs |
|
|
| Neurophysiology |
Presynaptic function: paired-pulse facilitation1 |
Decreased
Description: Decreased paired pulse faciliation
Exp Paradigm: Response to two pulses separated by varying interstimulus intervals and taking the ratio
|
Field potential recordings |
8-12 weeks |
| |
|
Description: Decreased paired pulse faciliation
Exp Paradigm: Response to two pulses separated by varying interstimulus intervals and taking the ratio |
|
|
| Developmental profile |
Size/growth1 |
Decreased
Description: Decreased body weight
Exp Paradigm: General observations
|
General observations |
Unreported |
| |
|
Description: Decreased body weight
Exp Paradigm: General observations |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Increased anxiety demonstrated by more time spent in dark side vs. light side
Exp Paradigm: Dark/light box test
|
Light-dark exploration test |
Unreported |
| |
|
Description: Increased anxiety demonstrated by more time spent in dark side vs. light side
Exp Paradigm: Dark/light box test |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Increased anxiety demonstrated by less time spent in center, more time in closed arms, and less time in open arms
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
Unreported |
| |
|
Description: Increased anxiety demonstrated by less time spent in center, more time in closed arms, and less time in open arms
Exp Paradigm: Elevated plus maze test |
|
|
| Learning & memory |
Cued or contextual fear conditioning1 |
Increased
Description: Increased cued conditioning anamolies demonstrated by increased freezing response in both context and cue fear conditioning
Exp Paradigm: Cued/contextual fear-conditioning paradigm
|
Fear conditioning test |
Unreported |
| |
|
Description: Increased cued conditioning anamolies demonstrated by increased freezing response in both context and cue fear conditioning
Exp Paradigm: Cued/contextual fear-conditioning paradigm |
|
|
| Learning & memory |
Cognitive flexibility: associative learning1 |
Decreased
Description: Decreased associative learning demonstrated by impaired extinction of freezing behavior to cue
Exp Paradigm: Cue conditioning training during extinction training
|
Fear conditioning test |
Unreported |
| |
|
Description: Decreased associative learning demonstrated by impaired extinction of freezing behavior to cue
Exp Paradigm: Cue conditioning training during extinction training |
|
|
| Learning & memory |
Object recognition memory1 |
Decreased
Description: Decreased novel object recognition memory demonstratedy by significantly less time spend with object
Exp Paradigm: Novel object recognition test
|
Novel object recognition test |
Unreported |
| |
|
Description: Decreased novel object recognition memory demonstratedy by significantly less time spend with object
Exp Paradigm: Novel object recognition test |
|
|
| Molecular profile |
Protein expression level evidence1 |
Increased
Description: Increased mecp2 within specific subregions of hippocampus
Exp Paradigm: Mecp2 protein expression
|
Immunohistochemistry |
Unreported |
| |
|
Description: Increased mecp2 within specific subregions of hippocampus
Exp Paradigm: Mecp2 protein expression |
|
|
| Molecular profile |
Protein expression level evidence1 |
Increased
Description: Increased expression of mecp2 protein in caudate-putamen, frontal cortex, hippocampus, and cerebellum
Exp Paradigm: Mecp2 protein expression
|
Western blot |
Unreported |
| |
|
Description: Increased expression of mecp2 protein in caudate-putamen, frontal cortex, hippocampus, and cerebellum
Exp Paradigm: Mecp2 protein expression |
|
|
| Motor phenotype |
General locomotor activity1 |
No change |
Home cage behavior |
Unreported |
| Neurophysiology |
Synaptic transmission1 |
No change |
Field potential recordings |
8-12 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
