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construct
M_HTR2A_4_KO_HM
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness1
Decreased
Description: Decreased layer iv thickness in s1 somatosensory cortical area
Exp Paradigm: Immunohistochemistry

Immunohistochemistry Unreported
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells1
Increased
Description: Increased neronal density throughout the neocortex, primary motor, somatosensory cortices and retrosplenial areas
Exp Paradigm: Immunohistochemistry

Immunohistochemistry Unreported
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness1
Increased
Description: Increased cortical thickness in s1 areas including jaw, frontal forelimb, barrel field and retrosplenial granular cortex
Exp Paradigm: Immunohistochemistry

Immunohistochemistry Unreported
Developmental profile Size/growth1
Decreased
Description: Slight decrease in mean body weight
Exp Paradigm: General observations

General observations Unreported
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size1 No change NA Unreported
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness1 No change Immunohistochemistry Unreported
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Motor phenotype,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Altamura C , et al. 2006
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