| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neurophysiology |
Miniature post synaptic currents: excitatory1 |
Increased
Description: Increased spontaneous excitatory postsnyaptic current frequency
Exp Paradigm: Whole-cell recordings of layer v pyramidal neurons in cortical slices
|
Whole-cell patch clamp |
Unreported |
| |
|
Description: Increased spontaneous excitatory postsnyaptic current frequency
Exp Paradigm: Whole-cell recordings of layer v pyramidal neurons in cortical slices |
|
|
| Emotion |
Anxiety1 |
Decreased
Description: Decreased anxiety demonstrated by increased exploring of environment and increased rearing
Exp Paradigm: Open field test
|
Open field test |
3-6 months |
| |
|
Description: Decreased anxiety demonstrated by increased exploring of environment and increased rearing
Exp Paradigm: Open field test |
|
|
| Emotion |
Anxiety1 |
Decreased
Description: Decreased anxiety demonstrated by decreased latency to begin feeding in novel environments
Exp Paradigm: Novelty-suppressed feeding paradigm
|
Novelty-induced hypophagia |
3-6 months |
| |
|
Description: Decreased anxiety demonstrated by decreased latency to begin feeding in novel environments
Exp Paradigm: Novelty-suppressed feeding paradigm |
|
|
| Emotion |
Anxiety1 |
Decreased
Description: Decreased anxiety demonstrated by increased time spent in open arms of test apparatus
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
3-6 months |
| |
|
Description: Decreased anxiety demonstrated by increased time spent in open arms of test apparatus
Exp Paradigm: Elevated plus maze test |
|
|
| Emotion |
Anxiety1 |
Decreased
Description: Decreased anxiety demonstrated by increased exploring of lit compartment
Exp Paradigm: Dark-light choice test
|
Light-dark exploration test |
3-6 months |
| |
|
Description: Decreased anxiety demonstrated by increased exploring of lit compartment
Exp Paradigm: Dark-light choice test |
|
|
| Emotion |
Depression1 |
No change |
Forced swim test |
3-6 months |
| Emotion |
Depression1 |
No change |
Tail suspension test |
3-6 months |
| Learning & memory |
Cued or contextual fear conditioning1 |
No change |
Fear conditioning test |
Unreported |
| Molecular profile |
Gene expression1 |
No change |
Quantitative pcr (qrt-pcr) |
Unreported |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: purkinje cells1 |
No change |
Histology |
Unreported |
| Neurophysiology |
Intrinsic membrane properties1 |
No change |
Whole-cell patch clamp |
Unreported |
| Physiological parameters |
Hormone levels1 |
No change |
High-performance liquid chromatography (hplc) |
Unreported |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Motor phenotype, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
