| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Increased
Description: Increased general locomotor activity
Exp Paradigm: Open field test
|
Open field test |
4-5 months |
| |
|
Description: Increased general locomotor activity
Exp Paradigm: Open field test |
|
|
| Social behavior |
Social approach1 |
Increased
Description: Increased social responses
Exp Paradigm: Behavioral response to introduction of intruder
|
Reciprocal social interaction test |
4 months |
| |
|
Description: Increased social responses
Exp Paradigm: Behavioral response to introduction of intruder |
|
|
| Physiological parameters |
Core body temperature1 |
Abnormal
Description: Abnormal temperature regulation
Exp Paradigm: Body temperature regulation following intracerebroventricular administration of grp
|
Body temperature measurement |
6 months |
| |
|
Description: Abnormal temperature regulation
Exp Paradigm: Body temperature regulation following intracerebroventricular administration of grp |
|
|
| Molecular profile |
Regulation of gene expression1 |
Decreased
Description: Absence of gene expression
Exp Paradigm: Grpr gene regulation
|
Quantitative pcr (qrt-pcr) |
Unreported |
| |
|
Description: Absence of gene expression
Exp Paradigm: Grpr gene regulation |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: Decreased protein expression
Exp Paradigm: Grpr protein expression
|
Autoradiographic analysis |
Unreported |
| |
|
Description: Decreased protein expression
Exp Paradigm: Grpr protein expression |
|
|
| Circadian sleep/wake cycle |
Circadian rhythm1 |
No change |
NA |
Unreported |
| Developmental profile |
Cardiovascular development and function1 |
No change |
Blood pressure measurement |
3-4 months |
| Developmental profile |
General characteristics1 |
No change |
General observations |
Unreported |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
3-4 months |
| Learning & memory |
Object recognition memory1 |
No change |
General observations |
3-4 months |
| Learning & memory |
Spatial reference memory1 |
No change |
Morris water maze test |
3-4 months |
| Motor phenotype |
Motor coordination and balance1 |
No change |
Accelerating rotarod test |
3-4 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
No change |
Histology |
Unreported |
| Neurophysiology |
Neurotransmitter release: serotonin1 |
No change |
High-performance liquid chromatography (hplc) |
5 months |
| Neurophysiology |
Neurotransmitter release: serotonin1 |
No change |
Immunohistochemistry |
4 months |
| Physiological parameters |
Glucose levels1 |
No change |
Elisa |
2-3 months |
| Physiological parameters |
Glucose levels1 |
No change |
Enzyme assay |
2-3 months |
| Physiological parameters |
Glucose levels1 |
No change |
Radioimmunoassay (ria) |
2-3 months |
| Physiological parameters |
Glucose levels1 |
No change |
Measurement of blood glucose |
2-3 months |
| Seizure |
Seizures1 |
No change |
NA |
Unreported |
| Sensory |
Pain or nociception1 |
No change |
Tail flick test |
Unreported |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
3-4 months |
| Social behavior |
Aggression1 |
No change |
Resident-intruder test |
4 months |
|
| Not Reported: |
Communications, Immune response, Maternal behavior, Physiological parameters, Repetitive behavior, |
