| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Sensory |
Itch sensation1 |
Decreased
Description: Decreased itch sensation
Exp Paradigm: Intrathecal administration of grpr agonist grp18-27
|
Intrathecal injection |
8-12 weeks |
| |
|
Description: Decreased itch sensation
Exp Paradigm: Intrathecal administration of grpr agonist grp18-27 |
|
|
| Sensory |
Itch sensation1 |
Decreased
Description: Decreased itch sensation
Exp Paradigm: Intradermal injection of puritogenic compount 48/80 (100 g per 50 l), par2, and chloroquine
|
Intradermal injection |
8-12 weeks |
| |
|
Description: Decreased itch sensation
Exp Paradigm: Intradermal injection of puritogenic compount 48/80 (100 g per 50 l), par2, and chloroquine |
|
|
| Physiological parameters |
Satiety response1 |
Decreased
Description: Decreased satiety response; no weight gain
Exp Paradigm: Intraperitoneal injection of increasing concentration of bombesin
|
Measurement of bombesin-induced feeding suppression |
Unreported |
| Physiological parameters |
Hormone levels1 |
Abnormal
Description: Amylase release is abnormal when the pancreatic acini are treated with bombesin
Exp Paradigm: Dispersed pancreatic acini incubated with bombesin
|
Hormone release by pancreatic acini |
Unreported |
| |
|
Description: Amylase release is abnormal when the pancreatic acini are treated with bombesin
Exp Paradigm: Dispersed pancreatic acini incubated with bombesin |
|
|
| Molecular profile |
Protein expression level evidence1 |
Abnormal
Description: Expressed in small and medium sized dorsal root ganglion neurons; located in lamina i and ii outer layer of spinal cord
Exp Paradigm: Grpr protein expression pattern
|
Immunocytochemistry |
8-12 weeks |
| |
|
Description: Expressed in small and medium sized dorsal root ganglion neurons; located in lamina i and ii outer layer of spinal cord
Exp Paradigm: Grpr protein expression pattern |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: Decreased protein expression
Exp Paradigm: Protein expression
|
Radioligand binding studies |
Unreported |
| |
|
Description: Decreased protein expression
Exp Paradigm: Protein expression |
|
|
| Developmental profile |
General characteristics1 |
No change |
Histology |
Unreported |
| Developmental profile |
General characteristics1 |
No change |
General observations |
Unreported |
| Physiological parameters |
Hormone levels1 |
No change |
Hormone release by pancreatic acini |
Unreported |
| Sensory |
Pain or nociception1 |
No change |
Paw injection test |
8-12 weeks |
| Sensory |
Pain or nociception1 |
No change |
Hot plate test |
8-12 weeks |
| Sensory |
Pain or nociception1 |
No change |
Tail flick test |
8-12 weeks |
| Sensory |
Pain or nociception1 |
No change |
Von frey filament test |
8-12 weeks |
| Sensory |
Pain or nociception1 |
No change |
Paw withdrawal test |
8-12 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
