| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
Decreased
Description: Decreased prefrontal cortex volume
Exp Paradigm: Volumetric analysis
|
Histology |
2-5 months |
| |
|
Description: Decreased prefrontal cortex volume
Exp Paradigm: Volumetric analysis |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal differentiation1 |
Decreased
Description: There is an increased number of mature granule cells in the outer granule cell layer of the dentate gyrus in mutant mice compared to the distribution seen in wild type littermates
Exp Paradigm: NA
|
NA |
2-5 months |
| |
|
Description: There is an increased number of mature granule cells in the outer granule cell layer of the dentate gyrus in mutant mice compared to the distribution seen in wild type littermates
Exp Paradigm: NA |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain cytoarchitecture1 |
Decreased
Description: Decreased number of immature neurons in dentate gyrus (dg)
Exp Paradigm: Immunocytochemical analysis of dentate gyrus (dg) using doublecortin (dcx) antibodies and brdu labeling
|
Immunohistochemistry |
2-5 months |
| |
|
Description: Decreased number of immature neurons in dentate gyrus (dg)
Exp Paradigm: Immunocytochemical analysis of dentate gyrus (dg) using doublecortin (dcx) antibodies and brdu labeling |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine density1 |
Decreased
Description: Mutant mice have decreased total dendritic length, and decreased number of spines of granule cells and layer v pyramidal neurons
Exp Paradigm: Confocal image analysis of coronal sections of granule cells
|
Immunohistochemistry |
2-3 months |
| |
|
Description: Mutant mice have decreased total dendritic length, and decreased number of spines of granule cells and layer v pyramidal neurons
Exp Paradigm: Confocal image analysis of coronal sections of granule cells |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: dendritic tree complexity1 |
Decreased
Description: The orientation angle and organization of mature and newborn granule cells is incorrect in the mutant mice
Exp Paradigm: Confocal image analysis of coronal sections of granule cells
|
Immunohistochemistry |
2-3 months |
| |
|
Description: The orientation angle and organization of mature and newborn granule cells is incorrect in the mutant mice
Exp Paradigm: Confocal image analysis of coronal sections of granule cells |
|
|
| Neurophysiology |
Synaptic plasticity1 |
Decreased
Description: Decreased short-term potentiation (stp) of ca1/ca3 hippocampal synapse
Exp Paradigm: Extracellular field recordings were made from stratum radiatum of ca1 after tetanization
|
Field potential recordings |
7-9 weeks |
| |
|
Description: Decreased short-term potentiation (stp) of ca1/ca3 hippocampal synapse
Exp Paradigm: Extracellular field recordings were made from stratum radiatum of ca1 after tetanization |
|
|
| Learning & memory |
Spatial working memory1 |
Decreased
Description: Decreased spatial working memory demonstrated by increased number of erros
Exp Paradigm: Two-choice delayed nonmatch to position (dnmp) task
|
Delayed non-match to place test |
2-5 months |
| |
|
Description: Decreased spatial working memory demonstrated by increased number of erros
Exp Paradigm: Two-choice delayed nonmatch to position (dnmp) task |
|
|
| Learning & memory |
Cued or contextual fear conditioning: memory of cue1 |
No change |
Fear conditioning test |
2-5 months |
| Learning & memory |
Object recognition memory1 |
No change |
Novel object recognition test |
2-5 months |
| Learning & memory |
Spatial reference memory1 |
No change |
Morris water maze test |
2-5 months |
| Learning & memory |
Spatial working memory1 |
No change |
Radial maze test |
2-5 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain cytoarchitecture1 |
No change |
Immunohistochemistry |
2-5 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
No change |
Immunohistochemistry |
2-3 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
No change |
Immunohistochemistry |
2-3 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
No change |
Histology |
2-5 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
No change |
Histology |
2-5 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
No change |
Histology |
2-5 months |
| Neurophysiology |
Synaptic plasticity1 |
No change |
Field potential recordings |
7-9 weeks |
| Neurophysiology |
Synaptic transmission1 |
No change |
Field potential recordings |
7-9 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Motor phenotype, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
