| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Increased
Description: Increased locomotion
Exp Paradigm: Male: open field test
|
Open field test |
4-9 months |
| |
|
Description: Increased locomotion
Exp Paradigm: Male: open field test |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
Decreased
Description: Decreased complexity of neurite arbor in primary cortical neurons
Exp Paradigm: Double immunostaining of primary neurons with anti-myc antibody
|
Immunohistochemistry |
Unreported |
| |
|
Description: Decreased complexity of neurite arbor in primary cortical neurons
Exp Paradigm: Double immunostaining of primary neurons with anti-myc antibody |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
Increased
Description: Increased volume of the lateral ventricles
Exp Paradigm: Magnetic resonance imaging (mri) analysis
|
Magnetic resonance imaging (mri) |
9 months |
| |
|
Description: Increased volume of the lateral ventricles
Exp Paradigm: Magnetic resonance imaging (mri) analysis |
|
|
| Social behavior |
Aggression1 |
Increased
Description: Increased aggressiveness
Exp Paradigm: Male mice: resident intruder
|
Resident-intruder test |
4-9 months |
| |
|
Description: Increased aggressiveness
Exp Paradigm: Male mice: resident intruder |
|
|
| Learning & memory |
Spatial reference memory1 |
Decreased
Description: Decreased spatial reference memory
Exp Paradigm: Female: morris water maze task
|
Morris water maze test |
4-9 months |
| |
|
Description: Decreased spatial reference memory
Exp Paradigm: Female: morris water maze task |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: Decreased levels of lis1 protein
Exp Paradigm: Lis1 protein expression
|
Western blot |
P7 |
| |
|
Description: Decreased levels of lis1 protein
Exp Paradigm: Lis1 protein expression |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: Decreased levels of disc1 protein
Exp Paradigm: Disc1 protein expression
|
Western blot |
P7 |
| |
|
Description: Decreased levels of disc1 protein
Exp Paradigm: Disc1 protein expression |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: Decreased levels of pre-synaptic marker snap-25
Exp Paradigm: Snap-25 protein expression
|
Western blot |
P7 |
| |
|
Description: Decreased levels of pre-synaptic marker snap-25
Exp Paradigm: Snap-25 protein expression |
|
|
| Developmental profile |
General characteristics1 |
No change |
General observations |
Unreported |
| Developmental profile |
Size/growth1 |
No change |
General observations |
Unreported |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
4-9 months |
| Learning & memory |
Spatial learning1 |
No change |
Morris water maze test |
4-9 months |
| Learning & memory |
Spatial reference memory1 |
No change |
Morris water maze test |
4-9 months |
| Molecular profile |
Protein expression level evidence1 |
No change |
Western blot |
P21, 9 months |
| Molecular profile |
Protein expression level evidence1 |
No change |
Western blot |
P7 |
| Molecular profile |
Protein expression level evidence1 |
No change |
Western blot |
P7 |
| Motor phenotype |
General locomotor activity1 |
No change |
Open field test |
4-9 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
No change |
Histology |
P7, p21, p80 |
| Sensory |
Olfaction1 |
No change |
Buried food test |
4-9 months |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
4-9 months |
| Social behavior |
Social interaction1 |
No change |
Reciprocal social interaction test |
4-9 months |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, |
