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M_DISC1_12_KO_HM_CLOZAPINE
Model Details
Change
No Change
Phenotypic Profile
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Repetitive behavior
Repetitive digging
1
Restored
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Description:
Clozapine treatment in mutants reduced the number of marbles buried to control levels. clozapine treatment had no effect on the performance of control mice.
Exp Paradigm:
NA
Marble-burying test
Adult
Description:
Clozapine treatment in mutants reduced the number of marbles buried to control levels. clozapine treatment had no effect on the performance of control mice.
Exp Paradigm:
NA
Repetitive behavior
Perseveration
1
Restored
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Description:
Clozapine treatment in mutants reduced the number of correction trials needed to reach the visual discrimination task criterion to control levels. as a result clozapine treatment in mutants reduced the perseveration index to control levels, in the early session of the visual discrimintation task. clozapine treatment had no effect on the performance of control mice.
Exp Paradigm:
Touching the incorrect stimulus in the correction trials was assayed as a measure of perseveration.
Operant conditioning paradigm
Adult
Description:
Clozapine treatment in mutants reduced the number of correction trials needed to reach the visual discrimination task criterion to control levels. as a result clozapine treatment in mutants reduced the perseveration index to control levels, in the early session of the visual discrimintation task. clozapine treatment had no effect on the performance of control mice.
Exp Paradigm:
Touching the incorrect stimulus in the correction trials was assayed as a measure of perseveration.
Learning & memory
Reward reinforced choice behavior
1
Restored
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Description:
Clozapine treatment in mutants reduced the total number of trials needed to reach the visual discrimination task criterion to control levels. clozapine treatment had no effect on the performance of control mice.
Exp Paradigm:
Mice are subjected to a touchscreen-based visual discrimination task involving discrimination of two stimuli for a liquid reward. pre-training included habituation, initial touch, must touch, must initiate, and punish incorrect, phases.
Operant conditioning paradigm
Adult
Description:
Clozapine treatment in mutants reduced the total number of trials needed to reach the visual discrimination task criterion to control levels. clozapine treatment had no effect on the performance of control mice.
Exp Paradigm:
Mice are subjected to a touchscreen-based visual discrimination task involving discrimination of two stimuli for a liquid reward. pre-training included habituation, initial touch, must touch, must initiate, and punish incorrect, phases.
Not Reported:
Circadian sleep/wake cycle
,
Communications
,
Developmental profile
,
Emotion
,
Immune response
,
Maternal behavior
,
Molecular profile
,
Motor phenotype
,
Neuroanatomy / ultrastructure / cytoarchitecture
,
Neurophysiology
,
Physiological parameters
,
Seizure
,
Sensory
,
Social behavior
,
References:
1:
Wulaer B , et al. 2018
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