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construct
M_DISC1_12_KO_HM_CLOZAPINE
Model Details
Change
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Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Repetitive behavior Repetitive digging1
Restored
Description: Clozapine treatment in mutants reduced the number of marbles buried to control levels. clozapine treatment had no effect on the performance of control mice.
Exp Paradigm: NA

Marble-burying test Adult
Repetitive behavior Perseveration1
Restored
Description: Clozapine treatment in mutants reduced the number of correction trials needed to reach the visual discrimination task criterion to control levels. as a result clozapine treatment in mutants reduced the perseveration index to control levels, in the early session of the visual discrimintation task. clozapine treatment had no effect on the performance of control mice.
Exp Paradigm: Touching the incorrect stimulus in the correction trials was assayed as a measure of perseveration.

Operant conditioning paradigm Adult
Learning & memory Reward reinforced choice behavior1
Restored
Description: Clozapine treatment in mutants reduced the total number of trials needed to reach the visual discrimination task criterion to control levels. clozapine treatment had no effect on the performance of control mice.
Exp Paradigm: Mice are subjected to a touchscreen-based visual discrimination task involving discrimination of two stimuli for a liquid reward. pre-training included habituation, initial touch, must touch, must initiate, and punish incorrect, phases.

Operant conditioning paradigm Adult
Not Reported: Circadian sleep/wake cycle,  Communications,  Developmental profile,  Emotion,  Immune response,  Maternal behavior,  Molecular profile,  Motor phenotype,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Wulaer B , et al. 2018
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