| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance1 |
Decreased
Description: Decreased latency to stay on rotarod
|
Accelerating rotarod test |
|
| |
|
Description: Decreased latency to stay on rotarod
|
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Size of cerebral ventricles: lateral ventricle1 |
Increased
Description: Enlarged ventricles in the brain
|
|
|
| |
|
Description: Enlarged ventricles in the brain
|
|
|
| Learning & memory |
Spatial reference memory1 |
Increased
Description: Increased interaction with object novel spatial location
|
Object-place recognition test |
|
| |
|
Description: Increased interaction with object novel spatial location
|
|
|
| Learning & memory |
Object recognition memory1 |
Increased
Description: Increased interaction with novel object
|
Novel object recognition test |
|
| |
|
Description: Increased interaction with novel object
|
|
|
| Molecular profile |
Targeted expression1 |
Increased
Description: Overexpression of transgene was estimated to be 11-fold higher than endogenous Disc1 protein
|
Western blot |
2 months |
| |
|
Description: Overexpression of transgene was estimated to be 11-fold higher than endogenous Disc1 protein
|
|
|
| Molecular profile |
Protein aggregation: neuronal1 |
Increased
Description: Neuronal, mainly perinuclear DISC1 aggregates throughout the brain; insolubility in ionic detergents upon biochemical fractionation
|
Western blot |
|
| |
|
Description: Neuronal, mainly perinuclear DISC1 aggregates throughout the brain; insolubility in ionic detergents upon biochemical fractionation
|
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
