| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Increased
Description: Increased general locomotor activity
Exp Paradigm: Open field test
|
Open field test |
3-8 months |
| |
|
Description: Increased general locomotor activity
Exp Paradigm: Open field test |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Size of cerebral ventricles: lateral ventricle1 |
Abnormal
Description: There is a significant change and/ reversal of the asymmetry between the left/right parts of the lateral ventricle in disc1 mutant mice compared to wild type littermates
Exp Paradigm: Ex vivo magnetic resonance imaging (mri) analysis
|
Magnetic resonance imaging (mri) |
6 weeks |
| |
|
Description: There is a significant change and/ reversal of the asymmetry between the left/right parts of the lateral ventricle in disc1 mutant mice compared to wild type littermates
Exp Paradigm: Ex vivo magnetic resonance imaging (mri) analysis |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Hippocampal morphology1 |
Abnormal
Description: There is a significant change in the ratio in volume of the left/right lobes of the hippocampus compared to wild type littermates
Exp Paradigm: Ex vivo magnetic resonance imaging (mri) analysis
|
Magnetic resonance imaging (mri) |
6 weeks |
| |
|
Description: There is a significant change in the ratio in volume of the left/right lobes of the hippocampus compared to wild type littermates
Exp Paradigm: Ex vivo magnetic resonance imaging (mri) analysis |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain morphology1 |
Increased
Description: Increased volume of lateral ventricles
Exp Paradigm: In vivo magnetic resonance imaging (mri) analysis
|
Magnetic resonance imaging (mri) |
6 weeks |
| |
|
Description: Increased volume of lateral ventricles
Exp Paradigm: In vivo magnetic resonance imaging (mri) analysis |
|
|
| Sensory |
Olfaction1 |
Decreased
Description: Decreased olfaction demonstrated by increased time taken to find hidden food
Exp Paradigm: Buried food-finding test
|
Buried food test |
3-8 months |
| |
|
Description: Decreased olfaction demonstrated by increased time taken to find hidden food
Exp Paradigm: Buried food-finding test |
|
|
| Emotion |
Depression1 |
Increased
Description: Increased depression assayed by increased immobility on surface of water
Exp Paradigm: Forced swim test
|
Forced swim test |
3-8 months |
| |
|
Description: Increased depression assayed by increased immobility on surface of water
Exp Paradigm: Forced swim test |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: Decreased parvalbumin expression in the medial prefrontal cortex
Exp Paradigm: Parvalbumin expression
|
Immunohistochemistry |
3 months |
| |
|
Description: Decreased parvalbumin expression in the medial prefrontal cortex
Exp Paradigm: Parvalbumin expression |
|
|
| Molecular profile |
Marker expression1 |
Decreased
Description: A significant reduction is seen in parvalbumin expression in the interneurons present in the medial prefrontal cortex of disc1 mutant mice
Exp Paradigm: NA
|
Immunohistochemistry |
3 months |
| |
|
Description: A significant reduction is seen in parvalbumin expression in the interneurons present in the medial prefrontal cortex of disc1 mutant mice
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
3-8 months |
| Emotion |
Anxiety1 |
No change |
Open field test |
3-8 months |
| Learning & memory |
Spatial reference memory1 |
No change |
Morris water maze test |
3-8 months |
| Learning & memory |
Spatial working memory1 |
No change |
Y-maze test |
3-8 months |
| Molecular profile |
Protein expression level evidence1 |
No change |
Immunohistochemistry |
3 months |
| Molecular profile |
Protein expression level evidence1 |
No change |
Immunohistochemistry |
3 months |
| Motor phenotype |
Motor coordination and balance1 |
No change |
Accelerating rotarod test |
3-8 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
No change |
Magnetic resonance imaging (mri) |
6, 13 weeks |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
3-8 months |
| Social behavior |
Social interaction1 |
No change |
Reciprocal social interaction test |
3-8 months |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, |
