| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neurophysiology |
Neuronal activation1 |
Increased
Description: Mutants show a larger number of c-fos positive cells in the dorsomedial striatum (dms) following the early visual discrimination session, compared to controls. mutants show no change in the number of c-fos positive cells in the dorsomedial striatum (dms) following the late visual discrimination session, compared to controls. mutants show no change in the number of c-fos positive cells in the dorsolateral striatum in the early visual discrimination phase, compared to controls, although both mutants and controls show an increase in the number of c-fos positive cells in the late session compared to the early visual discrimination session.
Exp Paradigm: NA
|
Immunohistochemistry |
Adult |
| |
|
Description: Mutants show a larger number of c-fos positive cells in the dorsomedial striatum (dms) following the early visual discrimination session, compared to controls. mutants show no change in the number of c-fos positive cells in the dorsomedial striatum (dms) following the late visual discrimination session, compared to controls. mutants show no change in the number of c-fos positive cells in the dorsolateral striatum in the early visual discrimination phase, compared to controls, although both mutants and controls show an increase in the number of c-fos positive cells in the late session compared to the early visual discrimination session.
Exp Paradigm: NA |
|
|
| Repetitive behavior |
Repetitive digging1 |
Increased
Description: Mutants buried more marbles than controls.
Exp Paradigm: NA
|
Marble-burying test |
Adult |
| |
|
Description: Mutants buried more marbles than controls.
Exp Paradigm: NA |
|
|
| Repetitive behavior |
Perseveration1 |
Increased
Description: Mutants show higher number of correction trials as a ratio of errors (perseveration index) in the early discrimination sessions, compared to controls. mutants show no change in perseveration index in the late discrimination sessions compared to controls.
Exp Paradigm: Touching the incorrect stimulus in the correction trials was assayed as a measure of perseveration.
|
Operant conditioning paradigm |
Adult |
| |
|
Description: Mutants show higher number of correction trials as a ratio of errors (perseveration index) in the early discrimination sessions, compared to controls. mutants show no change in perseveration index in the late discrimination sessions compared to controls.
Exp Paradigm: Touching the incorrect stimulus in the correction trials was assayed as a measure of perseveration. |
|
|
| Social behavior |
Nest building behavior1 |
Increased
Description: Mutants shredded more of the provided nestlets than controls, indicating an increase in repetitive behavior.
Exp Paradigm: NA
|
Nest building assay |
Adult |
| |
|
Description: Mutants shredded more of the provided nestlets than controls, indicating an increase in repetitive behavior.
Exp Paradigm: NA |
|
|
| Learning & memory |
Reward reinforced choice behavior1 |
Decreased
Description: Mutants show no change in the pre-training phase compared to controls. mutants needed more trials to reach criterion for reward and performed more correction trials, compared to controls, in the visual discrimination task. mutants showed fewer correct responses in the early phase of the visual discrimination task compared to controls. mutants show no change in capacity to ultimately attain the same level of accuracy as controls.
Exp Paradigm: Mice are subjected to a touchscreen-based visual discrimination task involving discrimination of two stimuli for a liquid reward. pre-training included habituation, initial touch, must touch, must initiate, and punish incorrect, phases.
|
Operant conditioning paradigm |
Adult |
| |
|
Description: Mutants show no change in the pre-training phase compared to controls. mutants needed more trials to reach criterion for reward and performed more correction trials, compared to controls, in the visual discrimination task. mutants showed fewer correct responses in the early phase of the visual discrimination task compared to controls. mutants show no change in capacity to ultimately attain the same level of accuracy as controls.
Exp Paradigm: Mice are subjected to a touchscreen-based visual discrimination task involving discrimination of two stimuli for a liquid reward. pre-training included habituation, initial touch, must touch, must initiate, and punish incorrect, phases. |
|
|
| Learning & memory |
Cognitive flexibility1 |
No change |
Operant conditioning paradigm |
Adult |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Seizure, Sensory, |
