| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine density1 |
Decreased
Description: Decreased dendritic complexity
Exp Paradigm: Transgene induced at pd7: dii (1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine) fluoresce rapid neuronal labeling method
|
Sholl analysis |
3-4 months |
| |
|
Description: Decreased dendritic complexity
Exp Paradigm: Transgene induced at pd7: dii (1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine) fluoresce rapid neuronal labeling method |
|
|
| Neurophysiology |
Synaptic transmission1 |
Decreased
Description: Decreased synaptic transmission and synaptic i/o function of hippocampal ca1 region
Exp Paradigm: Transgene induced at pd7: measurement of field excitatory postsynaptic potential (fepsp) from hippocampal ca1 slices
|
Field potential recordings |
3-4 months |
| |
|
Description: Decreased synaptic transmission and synaptic i/o function of hippocampal ca1 region
Exp Paradigm: Transgene induced at pd7: measurement of field excitatory postsynaptic potential (fepsp) from hippocampal ca1 slices |
|
|
| Social behavior |
Social approach1 |
Decreased
Description: Decreased social approach demonstrated by shorter time spent in unfamiliar mouse chamber
Exp Paradigm: Transgene induced at pd7: social preference test in tripartite chamber
|
Three-chamber social approach test |
3-12 months |
| |
|
Description: Decreased social approach demonstrated by shorter time spent in unfamiliar mouse chamber
Exp Paradigm: Transgene induced at pd7: social preference test in tripartite chamber |
|
|
| Emotion |
Depression1 |
Increased
Description: Increased depressive traits demonstrated by shorter latency to floating reaction
Exp Paradigm: Transgene induced at pd7: forced swim test
|
Forced swim test |
3-12 months |
| |
|
Description: Increased depressive traits demonstrated by shorter latency to floating reaction
Exp Paradigm: Transgene induced at pd7: forced swim test |
|
|
| Learning & memory |
Spatial working memory1 |
Decreased
Description: Decreased spatial working memory demonstrated by decreased percentage of correct choices
Exp Paradigm: Transgene induced at pd7: delayed nonmatched to place task
|
Delayed non-match to place test |
3-12 months |
| |
|
Description: Decreased spatial working memory demonstrated by decreased percentage of correct choices
Exp Paradigm: Transgene induced at pd7: delayed nonmatched to place task |
|
|
| Developmental profile |
General characteristics1 |
No change |
General observations |
3-12 months |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
3-12 months |
| Emotion |
Depression1 |
No change |
Forced swim test |
3-12 months |
| Learning & memory |
Spatial working memory1 |
No change |
Delayed non-match to place test |
3-12 months |
| Motor phenotype |
General locomotor activity1 |
No change |
Open field test |
3-12 months |
| Neurophysiology |
Presynaptic function: paired-pulse facilitation1 |
No change |
Paired-pulse ratio |
3-4 months |
| Neurophysiology |
Synaptic plasticity1 |
No change |
Long term potentiation (ltp) |
3-4 months |
| Social behavior |
Social approach1 |
No change |
Three-chamber social approach test |
3-12 months |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Molecular profile, Physiological parameters, Repetitive behavior, Seizure, Sensory, |
