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Animal Model >> null >> Z_MECP2_2_KO_HM_TNFA Construct Details |
| Model Details :Z_MECP2_2_KO_HM_TNFA
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Model Type |
RESCUE-Genetic
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Model Genotype |
Homozygous
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Mutation |
Mutant line contains a premature stop codon in the mecp2 gene (mecp2^Q63*) that truncates the protein before the methyl binding domain (MBD) and transcriptional repression domain (TRD). mecp2-null zebrafish larvae were injected with plasmid encoding full-length tnfa mRNA. |
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Allele Type |
Knockout |
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Strain of Origin |
AB |
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Genetic Background |
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ES Cell Line |
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Mutant ES Cell Line |
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Model Source |
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Reference |
van der Vaart M , et al. 2017
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