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Animal Model >> null >> Z_MECP2_2_KO_HM Construct Details |
| Model Details :Z_MECP2_2_KO_HM
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Model Type |
Genetic
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Model Genotype |
Homozygous
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Mutation |
Mecp2 null mutants carried q63/q63 nonsense mutation generated through N-ethyl-N-nitrosourea (ENU)-mutagenesis. Mutant line contains a premature stop codon in the mecp2 gene that truncates the protein before the methyl binding domain (MBD) and transcriptional repression domain (TRD). |
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Allele Type |
Knockout |
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Strain of Origin |
AB |
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Genetic Background |
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ES Cell Line |
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Mutant ES Cell Line |
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Model Source |
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Reference |
Leong WY , et al. 2016,
van der Vaart M , et al. 2017
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