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Animal Model >> null >> Z_CNTNAP2A_3_DM_HT Construct Details |
| Model Details :Z_CNTNAP2A_3_DM_HT
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Model Type |
Genetic
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Model Genotype |
Heterozygous/heterozygous
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Mutation |
Double heterozygous knockout mutants were generated by two loss-of-function mutations: delta 121 in exon 3 of cntnap2a (cntnap2a^delta121/+) and a 31 nucleotide insertion in exon 4 for cntnap2b (cntnap2b^31i/+), using zinc finger nucleases. These mutations cause a premature stop codon within the discoidin domain and result in loss of function. Fish carrying these alleles were crossed to generate cntnap2a^delta121/+-cntnap2b^31i/+. |
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Allele Type |
Loss-of-function |
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Strain of Origin |
Not specified |
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Genetic Background |
Not specified |
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ES Cell Line |
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Mutant ES Cell Line |
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Model Source |
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Reference |
Hoffman EJ , et al. 2016
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