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Animal Model >> null >> Z_CNTNAP2A_2_DM_HM Construct Details |
| Model Details :Z_CNTNAP2A_2_DM_HM
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Model Type |
Genetic
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Model Genotype |
Homozygous/homozygous
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Mutation |
Double knockout mutants were generated by two loss-of-function mutations , delta 25 in exon3 of cntnap2a and delta 7 in exon 2 for cntnap2b, using zinc finger nucleases. These mutations cause a premature stop codon wwithin the discoidin domain and result in loss of function. Fish carrying were crossed to generate cntnap2a^delta25/delta25-cntnap2b^delta7/delta7. |
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Allele Type |
Loss-of-function |
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Strain of Origin |
Not specified |
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Genetic Background |
Not specified |
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ES Cell Line |
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Mutant ES Cell Line |
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Model Source |
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Reference |
Hoffman EJ , et al. 2016
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