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Animal Model >> null >> M_NLGN3_34_CKO_HM Construct Details |
| Model Details :M_NLGN3_34_CKO_HM
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Model Type |
Genetic LOF
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Model Genotype |
Hemizygous
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Mutation |
Knockout mouse model lacking exon 7 through Cre deletion. Exon 7 encodes a half of the extracellular domain, and skipping of this exon is predicted to lead to a frame shift and a premature stop codon. Nlgn3 exon 7-deleted mice were generated by crossing heterozygous female XX^fR/C mice, which carry floxed exon 7 with a point mutation corresponding to the human NLGN3 R451C, with nestin-Cre transgenic male mice (+/nestin-cre) carrying the cre recombinase gene under the control of the rat nestin promoter and enhancer. |
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Allele Type |
knockout |
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Strain of Origin |
C57Bl/6 |
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Genetic Background |
C57Bl/6 |
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ES Cell Line |
NA |
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Mutant ES Cell Line |
NA |
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Model Source |
33758193 |
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Reference |
Yoshida T et al. 2021
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