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Animal Model >> null >> M_NLGN3_33_KI_HE_MF-AA Construct Details |
| Model Details :M_NLGN3_33_KI_HE_MF-AA
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Model Type |
Genetic LOF
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Model Genotype |
Hemizygous
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Mutation |
Knock-in mutant mice with the MF/AA mutation were generated using CRISPR/Cas9 genome editing. MF/AA consists of M614A and F615A double mutations which disturbs the interface between PTPĪ“ Ig2 and the C-terminal tail of NLGN3 ECD without any effect on the interaction with NRXNs. |
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Allele Type |
knockin |
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Strain of Origin |
C57Bl/6 |
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Genetic Background |
C57Bl/6 |
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ES Cell Line |
NA |
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Mutant ES Cell Line |
NA |
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Model Source |
33758193 |
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Reference |
Yoshida T et al. 2021
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