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Animal Model >> null >> M_NLGN3_32_KI_HE_HSE-AAA Construct Details |
| Model Details :M_NLGN3_32_KI_HE_HSE-AAA
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Model Type |
Genetic LOF
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Model Genotype |
Hemizygous
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Mutation |
Knock-in mutant mice with the HSE/AAA mutation were generated using CRISPR/Cas9 genome editing. The mutations consists of H279A S280A and E281A triple mutation (HSE/AAA) altering His279, Ser380, and Glu281, which comprise a near the interaction site for PTPĪ“ and NRXNs. |
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Allele Type |
knockin |
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Strain of Origin |
C57Bl/6 |
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Genetic Background |
C57Bl/6 |
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ES Cell Line |
NA |
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Mutant ES Cell Line |
NA |
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Model Source |
33758193 |
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Reference |
Yoshida T et al. 2021
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