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Animal Model >> null >> M_NLGN3_26_KI_R451C_URB Construct Details |
| Model Details :M_NLGN3_26_KI_R451C_URB
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Model Type |
RESCUE-Pharmaceutical
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Model Genotype |
Hemizygous
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Mutation |
Mice harboring the mutation of CGT (arginine 451) to TGC (cysteine 451) in exon 7 were treated with 1micromolar fatty acid amide hydrolase (FAAH) inhibitor URB 597 for 30 minutes, to investigate whether there was a deficit in endocannabinoid production in mutant striatal spiny projection neurons. |
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Allele Type |
ASD LOF mutation |
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Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+ |
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Genetic Background |
B6*129 |
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ES Cell Line |
Not Specified |
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Mutant ES Cell Line |
Not Specified |
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Model Source |
Sudhof laboratory (PMID 17823315 ) |
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Reference |
Martella G , et al. 2017
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